論文

査読有り 国際誌
2020年1月

Antibodies against nephronectin ameliorate anti-type II collagen-induced arthritis in mice.

FEBS open bio
  • Shigeyuki Kon
  • ,
  • Machiko Honda
  • ,
  • Kiyoshi Ishikawa
  • ,
  • Masahiro Maeda
  • ,
  • Tatsuya Segawa

10
1
開始ページ
107
終了ページ
117
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/2211-5463.12758

The extracellular matrix protein nephronectin (Npnt) is known to be critical for kidney development, but its function in inflammatory diseases is unknown. Here, we developed a new enzyme-linked immunosorbent assay system to detect Npnt in various autoimmune diseases, which revealed that plasma Npnt levels are increased in various mouse autoimmune models. We also report that antibodies against the α8β1 integrin-binding region of Npnt protect mice from anti-type II collagen-induced arthritis, suggesting that Npnt may be a potential therapeutic target molecule for the prevention of autoimmune arthritis.

リンク情報
DOI
https://doi.org/10.1002/2211-5463.12758
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31705832
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943231

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