Yasuhiko Ito

Profile Information

Affiliation: Juntendo University

J-GLOBAL ID: 201801015026312170
researchmap Member ID: B000330569

Research Interests

Research Areas

Life sciences / Tumor biology / 癌の転移のメカニズムの解明と治療への応用

Research History

Jun, 2021 - Present

Department of Immunological Diagnosis, Juntendo University Graduate School of Medicine
Jan, 2020 - May, 2021

Department of Immunological Diagnosis, Juntendo University Graduate School of Medicine
Apr, 2019 - Dec, 2019

Faculty of Medicine, Juntendo University
Jan, 2018 - Mar, 2019

Faculty of Medicine, Juntendo University
Mar, 2012 - Dec, 2017

Faculty of Medicine, Juntendo University
Sep, 2010 - Feb, 2012

研究補助員, 国立成育医療研究センター
Jul, 2003 - Aug, 2010

株式会社プライミューン
May, 2002 - Jun, 2003

久留米大学個別医療研究開発産学地域共同機構
Sep, 1999 - May, 2000

メルク・ジャパン株式会社
Apr, 1993 - Aug, 1999

アレルギー・免疫研究部, 国立小児医療研究センター
Mar, 1990 - Mar, 1993

第一研究部, 大阪バイオサイエンス研究所
Apr, 1989 - Feb, 1990

水無瀬研究所, 小野薬品工業株式会社

Education

Apr, 1984 - Mar, 1989

生物化学専攻, 理学研究科, 大阪大学大学院
Apr, 1982 - Mar, 1984

Tokyo University of Agriculture and Technology
Apr, 1977 - Mar, 1981

Faculty of Agriculture, Tokyo University of Agriculture and Technology

Papers

Increased <scp>RUNX3</scp> expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts

Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo …

Cancer Medicine, Aug 28, 2023
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.

Moe Iwai, Miniwan Tulafu, Shinsaku Togo, Hideya Kawaji, Kotaro Kadoya, Yukiko Namba, Jin Jin, Junko Watanabe, Takahiro Okabe, Moulid Hidayat …

Molecular oncology, 15(5) 1507-1527, May, 2021 Peer-reviewed
Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state.

Kosuke Mizukoshi, Yu Okazawa, Hiroshi Haeno, Yu Koyama, Kaidiliayi Sulidan, Hiromitsu Komiyama, Harumi Saeki, Naomi Ohtsuji, Yasuhiko Ito, Yutaka Kojima …

Int J Cancer, 146(9) 2547-2562, 2020 Peer-reviewed
癌関連線維芽細胞による中間型上皮間葉移行を呈した高転移性の乳癌細胞クラスター形成(CAF-induced partial epithelial-mesenchymal transition mediates formation of metastatic human breast tumor cell clusters)

折茂彰, 伊藤恭彦, 目澤義弘, 醍醐弥太郎, 樋野興夫, 竹田和由, 浜田道昭, 松村優子

日本癌学会総会記事, 78回 E-1041, Sep, 2019 Peer-reviewed
Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.

Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, Toru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, Takumi Itoh …

Life science alliance, 2, 2019 Peer-reviewed
癌内線維芽細胞と癌進展・悪性化

伊藤匠, 松村優子, 伊藤恭彦, 折茂彰

呼吸, 34(8) 758-766, Aug, 2015
Critical role of T cell migration in bacterial superantigen-mediated shock in mice

H Kano, Y Ito, K Matsuoka, T Nakajima, T Iwata, T Kohsaka, H Saito, J Abe

Clin Immunol, 110(2) 159-171, Feb, 2004 Peer-reviewed
Crystallization and preliminary X-ray analysis of Yersinia pseudotuberculosis-derived mitogen

R Donadini, M Wahlberga, T Kohsaka, Y Ito, BA Fields

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59 1330-1332, Jul, 2003 Peer-reviewed
Role of T cells and gamma interferon in Yersinia pseudotuberculosis -derived mitogen (YPM)-induced toxicity in mice

Kano H, Ito Y, Matsuoka K, Nakajima T, Iwata T, Kohsaka T, Saito H, Abe J

Adv. Exp. Med. Biol., 110 159-171, 2003 Peer-reviewed
Characterization and distribution of a new enterotoxin-related superantigen produced by Staphylococcus aureus

J Abe, Y Ito, M Onimaru, T Kohsaka, T Takeda

MICROBIOLOGY AND IMMUNOLOGY, 44(2) 79-88, 2000 Peer-reviewed
Analysis of functional regions of YPM, a superantigen derived from gram-negative bacteria

Y Ito, G Seprenyi, J Abe, T Kohsaka

EUROPEAN JOURNAL OF BIOCHEMISTRY, 263(2) 326-337, Jul, 1999 Peer-reviewed
Generated single point-mutations can considerably dismantle the lymphocyte overstimulation induced by Yersinia pseudotuberculosis superantigen

G Seprenyi, Y Ito, T Kohsaka

CELLULAR IMMUNOLOGY, 192(2) 96-106, Mar, 1999 Peer-reviewed
Clinical role for a superantigen in Yersinia pseudotuberculosis infection

J Abe, M Onimaru, S Matsumoto, S Noma, K Baba, Y Ito, T Kohsaka, T Takeda

JOURNAL OF CLINICAL INVESTIGATION, 99(8) 1823-1830, Apr, 1997 Peer-reviewed
SEQUENCE-ANALYSIS OF THE GENE FOR A NOVEL SUPERANTIGEN PRODUCED BY YERSINIA-PSEUDOTUBERCULOSIS AND EXPRESSION OF THE RECOMBINANT PROTEIN

Y ITO, J ABE, K YOSHINO, T TAKEDA, T KOHSAKA

JOURNAL OF IMMUNOLOGY, 154(11) 5896-5906, Jun, 1995 Peer-reviewed
Nucleotide sequence of the gene encoding a novel superantigen (YPM) produced by Yersinia pseudotuberculosis and the geographical heterogeneity in the prevalence of the gene

T. Takeda, K. Yoshino, T. Ramamurthy, Y. Ito, J. Abe, T. Kohsaka, H. Fukushima

Japanese Journal of Medical Science and Biology, 48(5-6) 261-262, 1995
Purification and gene cloning of a superantigen (YPM) produced by a patient strain of Yersinia pseudotuberculosis

T Takeda, K Yoshino, Y Itoh, J Abe, Y Shimonishi, T Kohsaka

Contrib. Microbiol. Immunol., 13 331-333, 1995 Peer-reviewed
STRUCTURAL-ANALYSIS OF THE FUNCTIONAL GENE AND PSEUDOGENE ENCODING THE MURINE GRANULOCYTE COLONY-STIMULATING-FACTOR RECEPTOR

Y ITO, Y SETO, CI BRANNAN, NG COPELAND, NA JENKINS, R FUKUNAGA, S NAGATA

EUROPEAN JOURNAL OF BIOCHEMISTRY, 220(3) 881-891, Mar, 1994 Peer-reviewed
PURIFICATION AND PARTIAL IDENTIFICATION OF BONE-INDUCING PROTEIN FROM A MURINE OSTEOSARCOMA

Y ITO

BIOCHEMICAL JOURNAL, 284 847-854, Jun, 1992 Peer-reviewed

Misc.

RUNX3 expression plays tumor-suppressive roles by inhibiting the inflammatory trait in human breast CAFs

Yu Koyama, Yoshihiro Mezawa, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara …

CANCER SCIENCE, 112 749-749, Feb, 2021
乳腺癌関連線維芽細胞においてRUNX3の発現は炎症性サイトカインの発現を抑制することで腫瘍抑制的に働く

小山侑, 目澤義弘, 伊藤恭彦, 小山拓洋, 醍醐弥太郎, 高野淳, 宮城洋平, 横瀬智之, 山下年成, 菅原圭亮 …

日本癌学会総会記事, 79回 PJ13-1, Oct, 2020
乳腺癌関連線維芽細胞においてRUNX3の発現は炎症性サイトカインの発現を抑制することで腫瘍抑制的に働く

小山侑, 目澤義弘, 伊藤恭彦, 小山拓洋, 醍醐弥太郎, 高野淳, 宮城洋平, 横瀬智之, 山下年成, 菅原圭亮 …

日本癌学会総会記事, 79回 PJ13-1, Oct, 2020
乳腺癌関連線維芽細胞におけるRUNX3の発現はTGF-βとSDF-1のクロストークおよびWNT-β-cateninシグナルを媒介する(RUNX3 expression mediates cross-talk between TGF-βand SDF-1 signaling and WNT-β-catenin signaling in human breast CAFs)

小山侑, 吉田剛, 伊藤恭彦, 目澤義弘, 小山拓洋, 菅原圭亮, 片倉朗, 折茂彰

日本癌学会総会記事, 78回 P-1104, Sep, 2019
癌関連線維芽細胞においてFOXO1は活性化筋線維芽細胞性を仲介する(Forkhead box protein O1 mediates the activated myofibroblastic state in carcinoma-associated fibroblasts)

小山拓洋, 目澤義弘, 小山侑, 伊藤恭彦, 菅原圭亮, 樋野興夫, 片倉朗, 折茂彰

日本癌学会総会記事, 78回 P-2284, Sep, 2019
CAFs induce formation of metastatic human breast tumor cell clusters with partial epithelial-mesenchymal transition

Akira Orimo, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliavi Sulidan, Yataro Daigo, Nadila Wali, Okio Hino, Kazuyoshi Takeda, Michiaki Hamada, Yuko Matsumura

CANCER SCIENCE, 109 797-797, Dec, 2018
乳腺癌関連線維芽細胞におけるRUNX3の発現はTGF-βとSDF-1のオートクラインシグナルを媒介する(RUNX3 expression mediates TGF-β and SDF-1 autocrine signaling in human breast CAF myofibroblasts)

小山侑, 酒寄詩織, 伊藤恭彦, 目澤義弘, 小山拓洋, 菅原圭亮, 樋野興夫, 片倉朗, 折茂彰

日本癌学会総会記事, 77回 2159-2159, Sep, 2018
大腸癌PDXモデルマウスにおける細胞クラスターによる転移形成

大久保捷奇, 水越幸輔, 岡澤裕, 波江野洋, 小見山博光, 佐伯春美, 伊藤恭彦, 五藤倫敏, 渡辺純夫, 樋野興夫 …

日本癌学会総会記事, 75回 P-2030, Oct, 2016
Fibrosis and tumor progression

折茂彰, 松村優子, 伊藤恭彦

呼吸器内科, 27(2) 142-148, Feb, 2015
患者大腸癌組織片の移植モデルにおける顕著な肝臓および肺への転移形成(The development of gross hepatic and pulmonary metastases in a patient-derived colorectal tumor xenograft model)

水越幸輔, 岡澤裕, 小見山博光, 藤井智明, 伊藤恭彦, 五藤倫敏, 垣生園子, 樋野興夫, 坂本一博, 折茂彰

日本癌学会総会記事, 72回 349-349, Oct, 2013
Molecular mechanism of Yersinia pseudotuberculosis-derived superantigen-mediated shock in mice

H Kano, K Matsuoka, Y Ito, T Nakajima, T Kohsaka, H Saito, J Abe

FASEB JOURNAL, 18(5) A1137-A1137, Mar, 2004
Pathogenic role of T cells in Yersinia pseudotuberculosis-derived superantigen-mediated shock in mice

H Kano, K Matsuoka, Y Ito, T Nakajima, T Kohsaka, H Saito, J Abe

FASEB JOURNAL, 17(7) C19-C19, Apr, 2003
Possible pathogenic role for a superantigen in Yersinia pseudotuberculosis infection.

J Abe, M Onimaru, Y Ito, T Kohsaka, T Takeda

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 99(1) 1041-1041, Jan, 1997
GENETIC-ANALYSIS OF A NOVEL SUPERANTIGEN PRODUCED BY YERSINIA-PSEUDOTUBERCULOSIS AND ITS EFFECT IN ACUTE-PHASE PATIENTS

J ABE, Y ITO, K YOSHINO, S MATSUMOTO, T TAKEDA, T KOHSAKA

FASEB JOURNAL, 9(3) A491-A491, Mar, 1995

Books and Other Publications

レンチウイルスベクターの効率的な回収法

伊藤恭彦, 目澤義弘, 小山侑, 折茂彰 (Role: Joint author)

羊土社, Dec, 2018
癌内線維芽細胞と癌悪性化

伊藤匠, 伊藤恭彦, 折茂彰 (Role: Joint author)

一般社団法人呼吸研究, 2015
Fibrosis and tumor progression

Akira Orimo, Yuko Matsumura, Yasuhiko Ito (Role: Joint author)

2015
がん細胞の浸潤・転移を促進するがん微小環境：がん内線維芽細胞を例に

松村優子, 伊藤恭彦, 折茂彰 (Role: Joint author)

学研メディカル秀潤社, 2014
the genus Yersinia

Kano H, Ito Y, Matsuoka K, Iwata T, Saito H, Kohsaka T, Abe J (Role: Joint author, Role of T cells and Gamma Interferon in Yersinia pseudotuberculosis-derived mitogen (YPM)-induced toxicity in mice)

Kluwer Academic Publishers, 2004
Kawasaki Disease

Takeda T, Abe J, Yoshino K, Ito Y, Matsumoto S, Shimonishi Y, Kohsaka T, Kobayashi N (Role: Joint author, Establishment of a novel superantigen produced by Yersinia pseudotuberculosis and its association with systemic Kawasaki disease-like symptoms)

Elsevier Science B.V., 1995
臨床免疫

伊藤恭彦, 阿部淳, 香坂隆夫 (Role: Joint author, エルシニア感染症とスーパー抗原)

科学評論社, 1995
Kawasaki Disease

Abe J, Takeda T, Ito Y, Noma S, Takeuchi N, Kobayashi N, Kohsaka T (Role: Joint author, TCR-V specificity of Staphylococcus aureus isolated from acute patients with Kawasaki syndrome)

Elsevier Science B.V., 1995

Presentations

抗panHLA2モノクロ―ナル抗体4713によるATL治療について

平野健志, 松岡周二, 水谷奈津子, 伊藤恭彦

第82回日本癌学会学術総会, Sep 23, 2023 Invited
リンパ腫におけるケラチンのタイプ別含有量に関する新しい知見

水谷奈津子, 伊藤恭彦, 武内詩織, 平野健志, 松岡周二

第82回日本癌学会学術総会, Sep 23, 2023 Invited
Therapeutic effects of newly established anti-CD10 mAb on lymphoma and lung cancer cell lines

Mizutani, Ito, Takeuchi et

The 80th Annual Meeting of the Japanese Cancer Assosiation, Oct 2, 2021
CAR B-therapy (Created Antibodies Reinforced by B cell therapy)

Takeuchi, Ito, Mizutani et

The 80th Annual Meeting of the Japanese Cancer Assosiation, Oct 1, 2021
RUNX3 expression plays tumor-suppressive roles by inhibiting the inflammatory traits in human CAFs

Koyama, Mezawa, Ito et a

The 79th Annual Meeting of the Japanese Cancer Assosiation, Oct 1, 2020
Establishment of a therapeutic antibody against NK lymphomas

Takeuch, Fukuhara, Egawa et al

The 79th Annual Meeting of the Japanese Cancer Assosiation, Oct 1, 2020
患者大腸癌細胞集団の中間型上皮間葉移行を介した浸潤・転移機構

水越幸輔, 岡澤裕, 波江野洋, 小山侑, 大久保捷奇, Kaidiliavi Sulidan, 伊藤恭彦, 小見山, 光, 杉本起一, 小島豊, 五藤倫敏, 垣生園子, 樋野興夫, 折茂彰, 坂本一博

第30回日本消化器癌発生学会総会, Nov 7, 2019
Forkhead box protein O1 mediates the activated myofibroblastic state in carcinoma-associated fibroblasts

Koyama T, Mezawa Y, Koyama Y

Sep 27, 2019
RUX3 expression mediates cross-talk berween TGF-b and SDF-1signaling and WNT-b-catenin signaling in human breast CAFs

Koyama Y, Yoshida G, Ito Y

Sep 26, 2019
CAF-induced partial epithelial-mesencymal transition mediates formation of metastatic human breast tumor cell clusters

Orimo A, Ito Y, Mezawa Y

Sep 26, 2019
RUNX3 expression mediates TGF-b and SDF-1 autorrine signaling in human breast CAF myofibroblasts

Koyama Y, Sakayori S, Ito Y

Sep 29, 2018
Endoglin mediates myofibroblastic and tumor-promoting carcinoma-associated fibroblasts in human breast carcinomas

Okubo S, Ito Y, Mezawa Y

Sep 28, 2018
CAFs induce formation of metastatic human breast tumor cell clusters with partial epithelial-mesencymal transition

Orimo A, Ito Y, Mezawa Y

Sep 28, 2018
Activation of Src signaling mediates carcinoma-associated fibroblast-promoted metastasis in human breast cancers

Ito Y, Matsumura Y, Mezawa Y

Sep 28, 2018
乳癌内線維芽細胞と癌浸潤・転移

折茂彰, 伊藤恭彦, 目澤義弘, Kaidiliavi Sulidan, Nadila Wali, 竹田省, 奥村康, 竹田和由, 樋野興夫, 浜田道昭, 松村優子

第27回日本癌病態治療研究会, May, 2018 Invited
患者大腸癌由来PDXおよびオルガノイドを使用した転移モデルの樹立

水越幸輔, 岡澤裕, 小山侑, 大久保捷奇, Kaidiliavi Sulidan, 伊藤恭彦, 小見山博光, 小島豊, 五藤倫敏, 垣生園子, 樋野興夫, 折茂彰, 坂本一博

第28回日本消化器癌発生学会総会, Nov 17, 2017
CAFpromote metastatic seeding of the highly epithelial human breast carcinoma cell cluster with a quasi-mesenchymal trait

Ito Y, Matsumura Y, Mezawa Y

Sep 30, 2017
CAFs boost mammary cancer invasion and metasatasis via formation of the epithelial and mesencymal tumor cell cluster

Orimo A, Ito Y, Mezawa Y

Sep 29, 2017
Carcinoma-associated fibroblasts upregulate endoglin expression to mediate their activated myofibroblastic traits

Okubo S, Mezawa Y, Ito Y

Sep 28, 2017
Multicellular tumor clusters seed metastases in colon patient-derived tumor xenograft

Okubo S, Mizukoshi K, Okazawa Y

Oct 7, 2016

Professional Memberships

THE JAPANESE CANCER ASSOCIATION

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特開平8-224097 スーパー抗原遺伝子

伊藤恭彦

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