論文

査読有り
2009年10月

Cutting Edge: Dab2 Is a FOXP3 Target Gene Required for Regulatory T Cell Function

JOURNAL OF IMMUNOLOGY
  • Nitya Jain
  • ,
  • Hai Nguyen
  • ,
  • Randall H. Friedline
  • ,
  • Nidhi Malhotra
  • ,
  • Michael Brehm
  • ,
  • Madoka Koyanagi
  • ,
  • Mark Bix
  • ,
  • Jonathan A. Cooper
  • ,
  • Cynthia A. Chambers
  • ,
  • Joonsoo Kang

183
7
開始ページ
4192
終了ページ
4196
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.4049/jimmunol.0902041
出版者・発行元
AMER ASSOC IMMUNOLOGISTS

FOXP3-expressing regulatory T (Treg) cells are vital for maintaining peripheral T cell tolerance and homeostasis. The mechanisms by which FOXP3 target genes orchestrate context-dependent Treg cell function are largely unknown. In this study we show that in mouse peripheral lymphocytes the Drosophila Disabled-2 (Dab2) homolog, a gene that is involved in enhancing TGF beta responses, is exclusively expressed in FOXP3(+) regulatory T cells. Dab2 is a direct target of FOXP3, and regulatory T cells lacking DAB2 are functionally impaired in vitro and in vivo. However, not all aspects of Treg cell function are perturbed, and DAB2 appears to be dispensable for Treg cell function in maintaining naive T cell homeostasis. The Journal of Immunology, 2009, 183: 4192-4196.

Web of Science ® 被引用回数 : 18

リンク情報
DOI
https://doi.org/10.4049/jimmunol.0902041
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19767570
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000270522500010&DestApp=WOS_CPL

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