Oct, 2009
Cutting Edge: Dab2 Is a FOXP3 Target Gene Required for Regulatory T Cell Function
JOURNAL OF IMMUNOLOGY
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- Volume
- 183
- Number
- 7
- First page
- 4192
- Last page
- 4196
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.4049/jimmunol.0902041
- Publisher
- AMER ASSOC IMMUNOLOGISTS
FOXP3-expressing regulatory T (Treg) cells are vital for maintaining peripheral T cell tolerance and homeostasis. The mechanisms by which FOXP3 target genes orchestrate context-dependent Treg cell function are largely unknown. In this study we show that in mouse peripheral lymphocytes the Drosophila Disabled-2 (Dab2) homolog, a gene that is involved in enhancing TGF beta responses, is exclusively expressed in FOXP3(+) regulatory T cells. Dab2 is a direct target of FOXP3, and regulatory T cells lacking DAB2 are functionally impaired in vitro and in vivo. However, not all aspects of Treg cell function are perturbed, and DAB2 appears to be dispensable for Treg cell function in maintaining naive T cell homeostasis. The Journal of Immunology, 2009, 183: 4192-4196.
- Link information
- ID information
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- DOI : 10.4049/jimmunol.0902041
- ISSN : 0022-1767
- Pubmed ID : 19767570
- Web of Science ID : WOS:000270522500010