論文

査読有り
2009年8月

Mina, an Il4 repressor, controls T helper type 2 bias

NATURE IMMUNOLOGY
  • Mariko Okamoto
  • ,
  • Melanie Van Stry
  • ,
  • Linda Chung
  • ,
  • Madoka Koyanagi
  • ,
  • Xizhang Sun
  • ,
  • Yoshie Suzuki
  • ,
  • Osamu Ohara
  • ,
  • Hiroshi Kitamura
  • ,
  • Atsushi Hijikata
  • ,
  • Masato Kubo
  • ,
  • Mark Bix

10
8
開始ページ
872
終了ページ
U98
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ni.1747
出版者・発行元
NATURE PUBLISHING GROUP

T helper type 2 (T(H)2) bias, which is the propensity of naive CD4(+) T cells to differentiate into interleukin 4 (IL-4)-secreting T(H)2 cells, is a genetic trait that affects susceptibility to infectious, autoimmune and allergic diseases. T(H)2 bias correlates with the amount of IL-4 initially secreted by newly activated helper T cells that feeds back positively through the pathway of the IL-4 receptor and the transcription factors STAT6 and GATA-3 to drive T(H)2 development. Here we identify Mina, a member of the jumonji C (JmjC) protein family, as a genetic determinant of T(H)2 bias. Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression. Our findings collectively provide mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in T(H)2 bias.

Web of Science ® 被引用回数 : 40

リンク情報
DOI
https://doi.org/10.1038/ni.1747
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19561615
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000268141400016&DestApp=WOS_CPL

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