論文

査読有り
2005年12月

CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4(+) T cells in vivo

CELLULAR IMMUNOLOGY
  • K Fukada
  • ,
  • M Koyanagi
  • ,
  • Y Arimura
  • ,
  • H Ogiuchi
  • ,
  • T Uchiyama
  • ,
  • J Yagi

238
2
開始ページ
103
終了ページ
112
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cellimm.2006.02.004
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

We previously reported that V beta 3(+) CD4(+) T cells maintained a protracted expansion, with the phenotypes of memory Th2 cells, for 30 days in C57BL/6 (B6) mice implanted with SEA-containing mini-osmotic pumps. In the present Study, we followed the fate of V beta 3(+) CD4(+) T cells in CD28(-/-) mice. V beta 3(+) CD4(+) T cells increased to a degree similar to that of B6 V beta 3(+) CD4(+) T cells until day 10 after implantation, then declined rapidly reaching the control level by 28 days. Remaining V beta 3(+) CD4(+) T cells at that time did not exhibit memory phenotypes nor Th2-deviated responses. The rapid drop in VP3(+) CD4(+) T cells in CD28(-/-) mice was attributable to upregulated induction of apoptosis owing to marginal inductions of Bcl-2 and Bcl-x(L). Collectively, these data indicate CD28 to play critical roles in the generation and maintenance of SEA-reactive CD4(+) T cells in vivo. (c) 2006 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1016/j.cellimm.2006.02.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16600196
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000237279300005&DestApp=WOS_CPL

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