論文

査読有り
2005年9月

EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in T(H)1 cells

JOURNAL OF BIOLOGICAL CHEMISTRY
  • M Koyanagi
  • ,
  • A Baguet
  • ,
  • J Martens
  • ,
  • R Margueron
  • ,
  • T Jenuwein
  • ,
  • M Bix

280
36
開始ページ
31470
終了ページ
31477
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1074/jbc.M504766200
出版者・発行元
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Differentiation of naive CD4 T cells toward the T helper 1 (T(H)1) and T helper 2 (T(H)2) fates involves the transcriptional repression and enhancement, respectively, of Il4 and Il13, adjacent chromosome 11 genes encoding the canonical T(H)2 cytokines interleukin-4 and interleukin-13. Proper execution of this developmental fate choice during immune responses is critical to host defense and, when misregulated, leads to susceptibility to infectious microbes and to allergic and autoimmune diseases. Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.

Web of Science ® 被引用回数 : 105

リンク情報
DOI
https://doi.org/10.1074/jbc.M504766200
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16009709
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000231665200018&DestApp=WOS_CPL

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