論文

査読有り
2005年7月

Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S

JOURNAL OF INFECTIOUS DISEASES
  • T Miyoshi-Akiyama
  • ,
  • D Takamatsu
  • ,
  • M Koyanagi
  • ,
  • JZ Zhao
  • ,
  • K Imanishi
  • ,
  • T Uchiyama

192
1
開始ページ
107
終了ページ
116
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1086/430617
出版者・発行元
UNIV CHICAGO PRESS

We analyzed the in vivo dynamics of peritoneal exudate cells (PECs) in mice injected with group A streptococcus (GAS). A live low-virulence strain, as well as heat-killed low- and high-virulence strains, significantly increased the number of PECs (primarily neutrophils), whereas a live high-virulence strain did not. When coinjected with thioglycollate, the live high-virulence strain, as well as most other GAS strains, suppressed the ability of thioglycollate to induce neutrophil exudation. This suppression was due to a cytocidal effect of GAS on exuded neutrophils rather than an inhibition of neutrophil migration. In addition, GAS enhanced the apoptosis of neutrophils. These cytocidal effects were significantly reduced by the deletion of functional streptolysin S from GAS. Our findings suggest that, in addition to the production of antiphagocytic factors and survival inside phagocytes, GAS uses a more aggressive method-the elimination of neutrophils-to evade the host's innate immune system.

Web of Science ® 被引用回数 : 59

リンク情報
DOI
https://doi.org/10.1086/430617
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15942900
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000229795300016&DestApp=WOS_CPL

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