論文

査読有り
2017年12月

Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype

JOURNAL OF INFECTIOUS DISEASES
  • Takayuki Chikata
  • ,
  • Hayato Murakoshi
  • ,
  • Madoka Koyanagi
  • ,
  • Kazutaka Honda
  • ,
  • Hiroyuki Gatanaga
  • ,
  • Shinichi Oka
  • ,
  • Masafumi Takiguchi

216
11
開始ページ
1415
終了ページ
1424
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/infdis/jix483
出版者・発行元
OXFORD UNIV PRESS INC

HLA-B*52:01-C*12:02, which is found in approximately 20% of all Japanese persons, is well known to be associated with ulcerative colitis and Takayasu arteritis. This haplotype is also known to be protective in individuals infected with human immunodeficiency virus (HIV) type 1. Recent studies showed that HLA-B*52:01-restricted HIV-1-specific T cells suppress HIV-1 and that HLA-C*12:02 together with KIR2DL2 play an important role in natural killer cell-mediated control of HIV-1. However, the role of HLA-C*12:02-restricted cytotoxic T lymphocytes (CTLs) in suppressing HIV-1 replication remains unknown. In the present study, we demonstrated that HLA-C*12:02-restricted CTLs specific for 2 immunodominant epitopes, Pol IY11 and Nef MY9, contributed to the suppression of HIV-1 replication in HIV-1-infected individuals. Further analysis demonstrated that these 2 HLA-C*12:02-restricted CTLs together with 4 HLA-B*52:01-restricted ones effectively suppressed HIV-1 in individuals with the HLA-B*52:01-C*12:02 haplotype. Thus, both HLA-C*12:02 and HLA-B*52:01 alleles contribute to HIV-1 suppression via both HIV-1-specific CTLs and natural killer cells in individuals with this haplotype.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1093/infdis/jix483
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28968792
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000417960300013&DestApp=WOS_CPL