Madoka Koyanagi

Profile Information

Affiliation: Faculty of Applied Life ScienceSchool of Animal Science, Nippon Veterinary and Life Science University

J-GLOBAL ID: 201601013591655505
researchmap Member ID: B000250522

External link: https://kaken.nii.ac.jp/d/r/00543399.ja.html

Research Interests

Research Areas

Life sciences / Immunology /

Research History

Apr, 2020 - Present

Faculty of Applied Life Science School of Animal Science, Nippon Veterinary and Life Science University
Apr, 2016 - Mar, 2020

School of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University
Apr, 2014 - Mar, 2016

School of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University
Feb, 2009 - Mar, 2014

Center for AIDS Research, Kumamoto University
Mar, 2006 - Jan, 2009

研究員, Department of Immunology, St.Jude Children’s Research Hospital
Oct, 2004 - Feb, 2006

研究員, Department of Immunology, University of Washington
Apr, 2004 - Sep, 2004

研究員, 理化学研究所免疫アレルギー科学総合研究センター

Education

Apr, 2000 - Mar, 2004

Tokyo Women's Medical University
Apr, 1998 - Mar, 2000

Kitasato University

Papers

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.

Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J Brumme, Hayato Murakoshi, Zabrina L Brumme, Shinichi Oka …

PLoS pathogens, 16(12) e1009177, Dec, 2020 Peer-reviewed
Comparative Expression Analysis of Stress-Inducible Genes in Murine Immune Cells.

Madoka Koyanagi, Yutaka Arimura

Immunological investigations, 1-19, Dec 13, 2019 Peer-reviewedLead author
Comparative Analysis of Bone Marrow-derived Mast Cell Differentiation in C57BL/6 and BALB/c Mice.

Nagashima M, Koyanagi M, Arimura Y

Immunological investigations, 1-18, Oct, 2018 Peer-reviewed
Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control.

Murakoshi H, Koyanagi M, Akahoshi T, Chikata T, Kuse N, Gatanaga H, Rowland-Jones SL, Oka S, Takiguchi M

EBioMedicine, 36 103-112, Sep, 2018 Peer-reviewed
A SNP uncoupling Mina expression from the TGFβ signaling pathway:

Shang L. Lian, Belgacem Mihi, Madoka Koyanagi, Toshinori Nakayama, Mark Bix

Immunity Inflammation and Disease, 6(1) 58-71, Mar 1, 2018 Peer-reviewed
HLA class I-mediated HIV-1 control in Vietnamese infected with HIV-1 subtype A/E

Takayuki Chikata, Giang Van Tran, Hayato Murakoshi, Tomohiro Akahoshi, Ying Qi, Vivek Naranbhai, Nozomi Kuse, Yoshiko Tamura, Madoka Koyanagi, Sachiko Sakai …

Journal of Virology, 92(5), Mar 1, 2018 Peer-reviewed
Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype

Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi

JOURNAL OF INFECTIOUS DISEASES, 216(11) 1415-1424, Dec, 2017 Peer-reviewed
Accumulation of Pol Mutations Selected by HLA-B*52:01-C*12:02 Protective Haplotype-Restricted Cytotoxic T Lymphocytes Causes Low Plasma Viral Load Due to Low Viral Fitness of Mutant Viruses

Hayato Murakoshi, Madoka Koyanagi, Takayuki Chikata, Mohammad Arif Rahman, Nozomi Kuse, Keiko Sakai, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi

JOURNAL OF VIROLOGY, 91(4), Feb, 2017 Peer-reviewedLead author
HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C*12:02/C*14:03

Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi …

CELL REPORTS, 17(9) 2210-2220, Nov, 2016 Peer-reviewed
Impaired Effect of HLA-A*24: 02-associated Mutation on HLA-B*35: 01-associated HIV-1 Control

Murakoshi Hayato, Akahoshi Tomohiro, Koyanagi Madoka, Chikata Takayuki, James Katherine L, Tamura Yoshiko, Kuse Nozomi, Sun Xiaoming, Gatanaga Hiroyuki, Rowland-Jones Sarah L …

AIDS RESEARCH AND HUMAN RETROVIRUSES, 32 168, Oct, 2016 Peer-reviewed
A comparative study of colorimetric cell proliferation assays in immune cells

Madoka Koyanagi, So Kawakabe, Yutaka Arimura

CYTOTECHNOLOGY, 68(4) 1489-1498, Aug, 2016 Peer-reviewedLead author
Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections

Nozomi Kuse, Mohammad Arif Rahman, Hayato Murakoshi, Giang Van Tran, Takayuki Chikata, Madoka Koyanagi, Kinh Van Nguyen, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi

JOURNAL OF VIROLOGY, 89(14) 7363-7372, Jul, 2015 Peer-reviewed
Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes

Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka …

JOURNAL OF VIROLOGY, 89(10) 5330-5339, May, 2015 Peer-reviewed
Effects of protein tyrosine phosphatase-PEST are reversed by Akt in T cells

Yutaka Arimura, Kazuhiko Shimizu, Madoka Koyanagi, Junji Yagi

CELLULAR SIGNALLING, 26(12) 2721-2729, Dec, 2014 Peer-reviewed
HIV Subtype Influences HLA- B*07: 02-Associated HIV Disease Outcome

Henrik N. Kloverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander …

AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(5) 468-475, May, 2014 Peer-reviewed
Identification of cross-clade CTL epitopes in HIV-1 clade A/E-infected individuals by using the clade B overlapping peptides

Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi

MICROBES AND INFECTION, 15(13) 874-886, Nov, 2013 Peer-reviewed
Transcriptional activation of Mina by Sp1/3 factors.

Lian S, Potula HH, Pillai MR, Van Stry M, Koyanagi M, Chung L, Watanabe M, Bix M

PloS one, 8(12) e80638, 2013 Peer-reviewed
Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope

Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kloverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce …

JOURNAL OF VIROLOGY, 86(23) 12643-12654, Dec, 2012 Peer-reviewedLead author
Selection of HLA-B57-associated Gag A146P mutant by HLA-B*48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese

Takuya Naruto, Hayato Murakoshi, Takayuki Chikata, Madoka Koyanagi, Yuka Kawashima, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi

MICROBES AND INFECTION, 13(8-9) 766-770, Aug, 2011 Peer-reviewed
Effective recognition of HIV-1-infected cells by HIV-1 integrase-specific HLA-B*4002-restricted T cells

Tamayo Watanabe, Hayato Murakoshi, Hiroyuki Gatanaga, Madoka Koyanagi, Shinichi Oka, Masafumi Takiguchi

MICROBES AND INFECTION, 13(2) 160-166, Feb, 2011 Peer-reviewed

Misc.

HLA‐B^*35:01保有者におけるHIV‐1感染促進の機序の解明

村越勇人, 小柳円, 赤星智寛, 近田貴敬, 久世望, 潟永博之, 潟永博之, 岡慎一, 岡慎一, 滝口雅文

日本エイズ学会誌, 20(4) 483, Nov 20, 2018
グルココルチコイド受容体の多型によるストレス感受性への影響

石川あゆ子, 小柳円, 有村裕

日本分子生物学会年会プログラム・要旨集(Web), 41st ROMBUNNO.3P‐0508 (WEB ONLY), 2018
Heligmosomoides polygyrusの感染初期動態と再感染防御メカニズム

島田実季, 小柳円, 有村裕, 石渡賢治

日本分子生物学会年会プログラム・要旨集(Web), 41st ROMBUNNO.2P‐0550 (WEB ONLY), 2018
線虫C.elegansはIgE産生機序解明のための実験材料になりうるか?

後藤夢実, 小柳円, 有村裕

日本生化学会大会(Web), 90th ROMBUNNO.1P‐1070 (WEB ONLY), 2017
In vitroにおけるサイトカインを用いた好酸球の分化・増殖への試み

岡美寿季, 小柳円, 有村裕

日本生化学会大会(Web), 90th ROMBUNNO.1P‐1074 (WEB ONLY), 2017
糖質コルチコイド受容体の遺伝子型によるストレス免疫反応への影響

小柳円

日本獣医生命科学大学研究報告(Web), (65) 53 (WEB ONLY), Dec 1, 2016
ベトナム人HIV‐1サブタイブA/E感染者コホートにおけるエイズ病態進行に関与するHLAアリルの探索

近田貴敬, VAN TranGiang, 村越勇人, 田村美子, 赤星智寛, 久世望, 阪井恵子, 小柳円, KINH VanNguyen, 滝口雅文 …

日本エイズ学会誌, 18(4) 456, Nov 20, 2016
ベトナム人HIV-1サブタイプA/E感染者コホートにおけるエイズ病態進行に関与するHLAアリルの探索

近田貴敬, Tran Giang Van, 村越勇人, 田村美子, 赤星智寛, 久世望, 阪井恵子, 小柳円, Nguyen Van Kinh, 滝口雅文

日本エイズ学会誌, 18(4) 456-456, Nov, 2016
HLA‐Cw12拘束性HIV‐1由来ペプチドの探索

山下諒也, 黒木喜美子, 渡邊洋介, 小柳円, 滝口雅文, 前仲勝実

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.1P‐0042 (WEB ONLY), 2016
C57BL/6とBALB/cマウスの骨髄細胞由来マスト細胞分化の比較

長島未希, 小柳円, 有村裕

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.3P‐0634 (WEB ONLY), 2016
ベトナム人慢性HIV‐1感染者におけるHIV‐1特異的細胞傷害性T細胞の網羅的解析

村越勇人, 田村美子, 丸山理恵, HOAI Dung Nguyen, VAN Giang Tran, 赤星智寛, 久世望, 近田貴敬, 阪井恵子, 小柳円 …

日本エイズ学会誌, 17(4) 378, Nov 20, 2015
ベトナム人HIV‐1感染者に見られるHIV‐1感染制御に関与したHIV‐1特異的細胞傷害性T細胞

田村美子, 村越勇人, 丸山理恵, HOAI Nguyen Dung, VAN Giang Tran, 赤星智寛, 久世望, 近田貴敬, 阪井恵子, 小柳円 …

日本エイズ学会誌, 17(4) 378, Nov 20, 2015
ベトナム人HIV‐1 subtype A/E感染者コホートにおけるHLA‐associated polymorphismの同定

近田貴敬, TRAN Van Giang, CARLSON Jonathan, 村越勇人, NGUYEN Hoai Dung, 田村美子, 赤星智寛, 久世望, 阪井恵子, 小柳円 …

日本エイズ学会誌, 17(4) 335, Nov 20, 2015
微生物学をリードするBasic Retrovirology ベトナム人HIV-1 subtype A/E感染者コホートにおけるHLA-associated polymorphismの同定

近田貴敬, Tran Van Giang, Carlson Jonathan, 村越勇人, Nguyen Hoai Dung, 田村美子, 赤星智寛, 久世望, 阪井恵子, 小柳円 …

日本エイズ学会誌, 17(4) 335-335, Nov, 2015
ベトナム人HIV-1感染者に見られるHIV-1感染制御に関与したHIV-1特異的細胞傷害性T細胞

田村美子, 村越勇人, 丸山理恵, Nguyen Hoai Dung, Tran Van Giang, 赤星智寛, 久世望, 近田貴敬, 阪井恵子, 小柳円 …

日本エイズ学会誌, 17(4) 378-378, Nov, 2015
ベトナム人慢性HIV-1感染者におけるHIV-1特異的細胞傷害性T細胞の網羅的解析

村越勇人, 田村美子, 丸山理恵, Nguyen Hoai Dung, Tran Van Giang, 赤星智寛, 久世望, 近田貴敬, 阪井恵子, 小柳円 …

日本エイズ学会誌, 17(4) 378-378, Nov, 2015
HEK293細胞を用いたHLA‐Cw12拘束性HIV‐1由来免疫制御ペプチドの探索

渡邊洋介, 黒木喜美子, 小柳円, 滝口雅文, 前仲勝実

日本分子生物学会年会プログラム・要旨集(Web), 37th 1P-0721 (WEB ONLY), 2014
Synergistic Effect of Multiple Ctls on Control of HIV-1 in Japanese Individuals Carrying HLA-B*35:01 Allele Associated with Rapid Disease Progression

M. Koyanagi, H. Murakoshi, H. Gatanaga, S. Oka, M. Takiguchi

AIDS RESEARCH AND HUMAN RETROVIRUSES, 29(11) A128-A129, Nov, 2013
エイズ進行を規定するHLAとその機序

小柳円, 滝口雅文

臨床免疫・アレルギー科, 60(5) 561-567, Nov, 2013
HIV由来ペプチドライブラリーを用いたHLA‐Cw12拘束性免疫制御ペプチドの同定

渡邊洋介, 黒木喜美子, 小柳円, 滝口雅文, 前仲勝実

日本分子生物学会年会プログラム・要旨集(Web), 36th 3P-0758 (WEB ONLY), 2013

Professional Memberships

JAPANESE SOCIETY FOR IMMUNOLOGY

Research Projects

糖質コルチコイド受容体遺伝子型の相違によるアレルギー反応への影響

科学研究費基盤研究C, 科学研究助成事業日本学術振興会, Apr, 2017 - Mar, 2020

小柳円
予後の悪いHLAを持つHIV-1感染者のHIV-1増殖抑制機序の解明

科学研究費若手研究B, 科学研究費助成事業日本学術振興会, Apr, 2013 - Mar, 2015

小柳円

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