論文

査読有り
2011年8月

Development of Direction Selectivity in Mouse Cortical Neurons

NEURON
  • Nathalie L. Rochefort
  • ,
  • Madoka Narushima
  • ,
  • Christine Grienberger
  • ,
  • Nima Marandi
  • ,
  • Daniel N. Hill
  • ,
  • Arthur Konnerth

71
3
開始ページ
425
終了ページ
432
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuron.2011.06.013
出版者・発行元
CELL PRESS

Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience. Here, we used two-photon calcium imaging to study the development of direction selectivity in layer 2/3 neurons of the mouse visual cortex in vivo. Surprisingly, just after eye opening nearly all orientation-selective neurons were also direction selective. During later development, the number of neurons responding to drifting gratings increased in parallel with the fraction of neurons that were orientation, but not direction, selective. Our experiments demonstrate that direction selectivity develops normally in dark-reared mice, indicating that the early development of direction selectivity is independent of visual experience. Furthermore, remarkable functional similarities exist between the development of direction selectivity in cortical neurons and the previously reported development of direction selectivity in the mouse retina. Together, these findings provide strong evidence that the development of orientation and direction selectivity in the mouse brain is distinctly different from that in ferrets.

Web of Science ® 被引用回数 : 113

リンク情報
DOI
https://doi.org/10.1016/j.neuron.2011.06.013
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000293991700007&DestApp=WOS_CPL
URL
http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(11)00518-6
ID情報
  • DOI : 10.1016/j.neuron.2011.06.013
  • ISSN : 0896-6273
  • eISSN : 1097-4199
  • Web of Science ID : WOS:000293991700007

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