論文

査読有り 国際誌
2018年3月

Diagnosis of pediatric neuroblastoma by urine cytology: A case report.

Diagnostic cytopathology
  • Shiori Nishikawa
  • ,
  • Hiroshi Noguchi
  • ,
  • Takako Tokumitsu
  • ,
  • Akinobu Ohno
  • ,
  • Sayaka Moriguchi-Goto
  • ,
  • Kazunari Maekawa
  • ,
  • Yujiro Asada
  • ,
  • Hiroshi Moritake
  • ,
  • Mariko Kinoshita
  • ,
  • Ai Yamada
  • ,
  • Kazunari Takamura
  • ,
  • Yuichiro Sato

46
3
開始ページ
280
終了ページ
283
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/dc.23831
出版者・発行元
John Wiley and Sons Inc.

Neuroblastomas are embryonal tumors arising from the neuronal crest cells of the synaptic nervous system. Findings from aspiration cytology have been reported, but there have been no reports of urine cytology findings. Here, we report a case of pediatric neuroblastoma characterized by urine cytology. A 2-year-old boy presented with abdominal pain, nausea, and loss of appetite. Computed tomography revealed a large tumor in the left suprarenal region with massive infiltration into the kidney. Urinary cytology showed highly cellular clusters composed of small, round, atypical cells with little cytoplasm and high nuclear/cytoplasmic ratio; nuclear molding was also noted in some places. Immunocytochemical staining was positive for synaptophysin and chromogranin A, and neuroblastoma was suggested by urine cytology. A biopsy of the left adrenal tumor later confirmed a diagnosis of poorly differentiated neuroblastoma. Urine cytology may be useful for rapid diagnosis and management of similar cases.

リンク情報
DOI
https://doi.org/10.1002/dc.23831
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28984419
ID情報
  • DOI : 10.1002/dc.23831
  • ISSN : 1097-0339
  • ISSN : 8755-1039
  • PubMed ID : 28984419
  • SCOPUS ID : 85030551071

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