論文

査読有り
2017年9月1日

Asymptomatic Plaques of Lower Peripheral Arteries and Their Association with Cardiovascular Disease: An Autopsy Study.

Journal of atherosclerosis and thrombosis
  • Eriko Nakamura
  • ,
  • Yuichiro Sato
  • ,
  • Takashi Iwakiri
  • ,
  • Atsushi Yamashita
  • ,
  • Sayaka Moriguchi-Goto
  • ,
  • Kazunari Maekawa
  • ,
  • Toshihiro Gi
  • ,
  • Yujiro Asada

24
9
開始ページ
921
終了ページ
927
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.5551/jat.39669
出版者・発行元
Japan Atherosclerosis Society

AIM: Patients with peripheral artery disease (PAD) have a high prevalence of cardiovascular morbidity and mortality; however, majority of patients with PAD are asymptomatic. This study aimed to histologically evaluate whether asymptomatic, lower extremity artery plaques are associated with systemic atherosclerosis and the onset of cardiovascular disease (CVD) events using autopsy cases. METHODS: We histologically investigated the atherosclerotic plaques of the common iliac, common carotid, coronary, and renal arteries from 121 autopsy cases without symptoms of PAD (mean age:67.6 years; 63% men; 83% non-CVD death). We evaluated the relationship between the degree of iliac artery atherosclerosis and that of other arteries, and also the presence of any CVD, myocardial infarction, stroke, and renal failure. RESULTS: Advanced atherosclerotic plaques (American Heart Association ≥4) were present in 86 (72%) common iliac arteries in these cases. These arteries also showed high frequencies of calcification (66%), intraplaque hemorrhage (42%), and plaque disruption (24%). These advanced lesions were associated with age (≥60 years), sex (male), hypertension, diabetes, and smoking habit (all P<0.05). Additionally, it was significantly associated with CVD (odds ratio, 95% confidence interval; 6.2, 2.2-22), myocardial infarction (6.4, 1.2-19), stroke (8.7, 1.7-16), and renal failure/hemodialysis (5.8, 1.1-11). Cases with advanced iliac artery plaques had advanced coronary and carotid atherosclerosis. CONCLUSION: These results indicate that asymptomatic advanced plaques are frequently observed in common iliac arteries, and are associated with generalized atherosclerosis and CVD events.

リンク情報
DOI
https://doi.org/10.5551/jat.39669
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28367862
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587518
ID情報
  • DOI : 10.5551/jat.39669
  • ISSN : 1880-3873
  • ISSN : 1340-3478
  • PubMed ID : 28367862
  • PubMed Central 記事ID : PMC5587518
  • SCOPUS ID : 85028682115

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