論文

査読有り
2014年

Primary central nervous system lymphoma in Miyazaki, southwestern Japan, a human T-lymphotropic virus Type-1 (HTLV-1)-endemic area: clinicopathological review of 31 cases.

Journal of clinical and experimental hematopathology : JCEH
  • Kazunari Maekawa
  • ,
  • Sayaka Moriguchi-Goto
  • ,
  • Ayako Kamiunten
  • ,
  • Yoko Kubuki
  • ,
  • Kazuya Shimoda
  • ,
  • Hideo Takeshima
  • ,
  • Yujiro Asada
  • ,
  • Kousuke Marutsuka

54
3
開始ページ
179
終了ページ
85
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3960/jslrt.54.179

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive brain tumor. The aim of this study was to clarify the prevalence of T-cell-type PCNSL (T-PCNSL) in a human T-lymphotropic virus type-1 (HTLV-1)-endemic area of Southwestern Japan. We retrospectively investigated 31 PCNSL cases diagnosed between 1996 and 2013 at the University of Miyazaki Hospital. These cases accounted for 4.4% of all nodal or extranodal malignant lymphomas. Histologically, most of these cases were diagnosed as diffuse large B-cell lymphoma, while only two cases were considered to be low-grade and high-grade B-cell lymphoma (not otherwise specified). No T-PCNSL was found in this series. In addition, Epstein-Barr virus-encoded RNAs were not detected by in situ hybridization in any of the cases. Overall, no T-PCNSL cases were found in 18 years in a region with a high frequency of HTLV-1 seropositivity, namely, Southwestern Japan. This suggests that PCNSL and lymphomas of other anatomical sites are biologically distinct.

リンク情報
DOI
https://doi.org/10.3960/jslrt.54.179
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25501108
ID情報
  • DOI : 10.3960/jslrt.54.179
  • ISSN : 1346-4280
  • eISSN : 1880-9952
  • PubMed ID : 25501108

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