論文

国際誌
2019年

C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome.

Case reports in obstetrics and gynecology
  • Yuichiro Sato
  • ,
  • Tomoko Yamaguchi
  • ,
  • Jyunsuke Muraoka
  • ,
  • Hajime Taniguchi
  • ,
  • Atsushi Kisanuki
  • ,
  • Kazunari Maekawa
  • ,
  • Atushi Yamashita
  • ,
  • Murasaki Aman
  • ,
  • Yuki Kodama
  • ,
  • Hiroshi Sameshima
  • ,
  • Yujiro Asada

2019
開始ページ
5863476
終了ページ
5863476
記述言語
英語
掲載種別
DOI
10.1155/2019/5863476

Neonatal lupus syndrome (NLS) is a rare, passively acquired autoimmune syndrome caused by maternal autoantibodies. We describe a case of a newborn with NLS and the accompanying placental findings. A female neonate was born by emergency cesarean delivery due to non-reassuring fetal status at 35 weeks and 3 days. This neonate had congenital erythematous and scar lesions on the face, back, and upper and lower extremities. Maternal and fetal anti-SSA and SSB antibodies were elevated and this baby was diagnosed as NLS. Histologically, the chorionic villi demonstrated capillary shrinkage. An immunohistochemical study revealed complement deposition (C4d) in the capillaries of the villi and umbilical vessels. Our findings suggest that maternal autoantibodies affect the inflammatory response of the fetus through the placenta and that C4d deposition may be useful for diagnosing NLS.

リンク情報
DOI
https://doi.org/10.1155/2019/5863476
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31019821
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452554
ID情報
  • DOI : 10.1155/2019/5863476
  • PubMed ID : 31019821
  • PubMed Central 記事ID : PMC6452554

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