論文

査読有り
2013年4月

Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering

JOURNAL OF DENTAL RESEARCH
  • A. Angelova Volponi
  • ,
  • M. Kawasaki
  • ,
  • P. T. Sharpe

92
4
開始ページ
329
終了ページ
334
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0022034513481041
出版者・発行元
SAGE PUBLICATIONS INC

Teeth develop from interactions between embryonic oral epithelium and neural-crest-derived mesenchyme. These cells can be separated into single-cell populations and recombined to form normal teeth, providing a basis for bioengineering new teeth if suitable, non-embryonic cell sources can be identified. We show here that cells can be isolated from adult human gingival tissue that can be expanded in vitro and, when combined with mouse embryonic tooth mesenchyme cells, form teeth. Teeth with developing roots can be produced from this cell combination following transplantation into renal capsules. These bioengineered teeth contain dentin and enamel with ameloblast-like cells and rests of Malassez of human origin.

リンク情報
DOI
https://doi.org/10.1177/0022034513481041
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000316270100005&DestApp=WOS_CPL
URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706174/
ID情報
  • DOI : 10.1177/0022034513481041
  • ISSN : 0022-0345
  • Web of Science ID : WOS:000316270100005

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