牧山明資 (Akitaka Makiyama) - マイポータル

基本情報

所属: 岐阜大学医学部附属病院がんセンター准教授

学位: 医学博士(九州大学大学院)

ORCID iD: https://orcid.org/0000-0002-4017-668X
J-GLOBAL ID: 202001019659199288
Researcher ID: AAU-7256-2020
researchmap会員ID: R000000874

論文

108

HER2 Protein Overexpression, mRNA Expression, and DNA Amplification Across Solid Tumors: Comparison of Next-Generation Sequencing-Based Assays With Immunohistochemistry.

Michiko Nagamine, Takao Fujisawa, Naoya Sakamoto, Yoshiaki Nakamura, Shigenori Kadowaki, Makoto Ueno, Shogen Boku, Yoshito Komatsu, Eiji Oki, Akitaka Makiyama …

JCO precision oncology 10 e2500413 2026年1月
Circulating Tumor DNA Profiling Reveals Genomic Evolution in Recurrent Gastric or Gastroesophageal Junction Cancer.

Ryohei Kawabata, Hiroyuki Takeda, Atsushi Ishiguro, Shinichi Nishina, Masazumi Takahashi, Shuhei Suzuki, Takahisa Suzuki, Jin Matsuyama, Yasufumi Otsuki, Yusuke Akamaru …

Molecular diagnosis & therapy 29(6) 839-847 2025年11月
Cancer cachexia onset and survival outcomes in metastatic colorectal cancer: Comparative assessment of the asian working group for cachexia and the European palliative care research collaborative criteria, and utility of modified glasgow prognostic score.

Hironori Fujii, Misato Kani, Daichi Watanabe, Yuto Miura, Wakana Chikaishi, Jesse Yu Tajima, Akitaka Makiyama, Yunami Yamada, Koichi Ohata, Chiemi Hirose …

International journal of colorectal disease 40(1) 164-164 2025年7月25日
Phase II Study (NO LIMIT, WJOG13320G) of First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High Advanced Gastric or Esophagogastric Junction Cancer.

Hisato Kawakami, Shigenori Kadowaki, Akitaka Makiyama, Masahiro Tsuda, Kenro Hirata, Naotoshi Sugimoto, Nozomu Machida, Hiroki Hara, Hidekazu Hirano, Taito Esaki …

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 43(19) 2184-2195 2025年7月
Landscape Analysis of <scp>CLDN18</scp> Expression and Isoform Distribution in Solid Tumors: Insights From <scp>MONSTAR</scp>‐<scp>SCREEN</scp>‐2 Study

Tadayoshi Hashimoto, Naoko Iida, Yoshiaki Nakamura, Norio Nonomura, Chigusa Morizane, Hiroji Iwata, Susumu Okano, Wataru Yamagami, Naoya Yamazaki, Shigenori Kadowaki …

Cancer Science 116(8) 2218-2231 2025年6月2日
Geriatric 8 score as a prognostic factor of the efficacy and safety of oxaliplatin-based chemotherapy in elderly patients with metastatic colorectal cancer.

Koki Hara, Wakana Chikaishi, Yunami Yamada, Hironori Fujii, Jesse Yu Tajima, Hirotoshi Iihara, Akitaka Makiyama, Daichi Watanabe, Koichi Ohata, Chiemi Hirose …

International journal of colorectal disease 40(1) 132-132 2025年5月30日
A phase two trial evaluating FOLFIRI plus aflibercept after failure of FOLFOXIRI plus bevacizumab in patients with unresectable metastatic colorectal cancer.

Koji Ando, Hironaga Satake, Mototsugu Shimokawa, Hisateru Yasui, Yuji Negoro, Tatsuya Kinjo, Junya Kizaki, Kenji Baba, Hiroyuki Orita, Keiji Hirata …

International journal of clinical oncology 30(3) 514-523 2025年3月
Nanoliposomal irinotecan with fluorouracil and folinic acid, FOLFIRINOX, and S-1 as second-line treatment for unresectable pancreatic cancer after gemcitabine/nab-paclitaxel.

Taro Shibuki, Taiga Otsuka, Mototsugu Shimokawa, Junichi Nakazawa, Shiho Arima, Masaru Fukahori, Keisuke Miwa, Yoshinobu Okabe, Futa Koga, Yujiro Ueda …

Scientific reports 14(1) 16906-16906 2024年7月23日
CONUT score as a predictor for anamorelin efficacy in patients with cancer cachexia receiving chemotherapy.

Hironori Fujii, Akitaka Makiyama, Kayoko Nishimura, Hirotoshi Iihara, Chiemi Hirose, Koichi Ohata, Yunami Yamada, Daichi Watanabe, Itaru Yasufuku, Naoki Okumura …

Journal of pharmaceutical health care and sciences 10(1) 36-36 2024年7月10日
A Phase II Study of FOLFIRI Plus Ziv-Aflibercept After Trifluridine/Tipiracil Plus Bevacizumab in Patients with Metastatic Colorectal Cancer: WJOG 11018G.

Toshihiko Matsumoto, Yoshiyuki Yamamoto, Masahito Kotaka, Toshiki Masuishi, Yasushi Tsuji, Hirokazu Shoji, Kenro Hirata, Takao Tsuduki, Akitaka Makiyama, Naoki Izawa …

Targeted oncology 19(2) 181-190 2024年3月
Prognostic impact of severe neutropenia in colorectal cancer patients treated with TAS-102 and bevacizumab, addressing immortal-time bias.

Daichi Watanabe, Hironori Fujii, Koichi Ohata, Hirotoshi Iihara, Akitaka Makiyama, Ryo Kobayashi, Chiemi Hirose, Shiori Hishida, Serika Matsuoka, Jesse Yu Tajima …

BMC cancer 23(1) 1078-1078 2023年11月8日
Efficacy and Safety of Oxaliplatin-based Regimens as First-line Chemotherapy in Elderly Patients With Metastatic Colorectal Cancer.

Seiji Yamamoto, Hironori Fujii, Kotaro Murayama, Hirotoshi Iihara, Daichi Watanabe, Yunami Yamada, Ryo Kobayashi, Shigeru Kiyama, Akitaka Makiyama, Kimihiko Urano …

Anticancer research 43(11) 5099-5105 2023年11月
Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression.

Hirokatsu Hayashi, Itaru Yasufuku, Toshiya Higashi, Wakana Chikaishi, Ryoma Yokoi, Masahiro Fukada, Yuta Sato, Ryuichi Asai, Jesse Yu Tajima, Chiemi Saigo …

Surgical case reports 9(1) 87-87 2023年5月22日
Emetogenicity and Risk Factors of Nausea and Vomiting in Patients With Metastatic Colorectal Cancer Receiving Trifluridine/Tipiracil and Bevacizumab Chemotherapy.

Serika Matsuoka, Hironori Fujii, Hirotoshi Iihara, Koichi Ohata, Chiemi Hirose, Daichi Watanabe, Shiori Sadaka, Shigeru Kiyama, Akitaka Makiyama, Takao Takahashi …

Anticancer research 43(5) 2351-2357 2023年5月
Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With RAS Wild-type, Left-Sided Metastatic Colorectal Cancer: A Randomized Clinical Trial.

Jun Watanabe, Kei Muro, Kohei Shitara, Kentaro Yamazaki, Manabu Shiozawa, Hisatsugu Ohori, Atsuo Takashima, Mitsuru Yokota, Akitaka Makiyama, Naoya Akazawa …

JAMA 329(15) 1271-1282 2023年4月18日
Trifluridine/tipiracil+bevacizumab (BEV) vs. fluoropyrimidine-irinotecan+BEV as second-line therapy for metastatic colorectal cancer: a randomised noninferiority trial

Yasutoshi Kuboki, Tetsuji Terazawa, Toshiki Masuishi, Masato Nakamura, Jun Watanabe, Hitoshi Ojima, Akitaka Makiyama, Masahito Kotaka, Hiroki Hara, Yoshinori Kagawa …

British Journal of Cancer 2023年3月4日
Gastric carcinosarcoma with FGFR2 amplification under long-term control with pazopanib: a case report and literature review

Hirokatsu Hayashi, Akitaka Makiyama, Naoki Okumura, Itaru Yasufuku, Chiemi Saigo, Tamotsu Takeuchi, Tatsuhiko Miyazaki, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Katsutoshi Murase …

BMC Gastroenterology 22(1) 2022年12月
Pattern of disease progression during third-line or later chemotherapy with nivolumab associated with poor prognosis in advanced gastric cancer: a multicenter retrospective study in Japan.

Masahiko Aoki, Shigenori Kadowaki, Naoki Takahashi, Takeshi Suzuki, Kotoe Oshima, Takayuki Ando, Yoshiyuki Yamamoto, Kentaro Kawakami, Yosuke Kito, Toshihiko Matsumoto …

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26(1) 132-144 2022年11月1日
Multicenter retrospective analysis of original versus modified FOLFIRINOX in metastatic pancreatic cancer: Results of the NAPOLEON study.

Junichi Nakazawa, Nobuhiro Tsuruta, Mototsugu Shimokawa, Machiko Kawahira, Shiho Arima, Akio Ido, Futa Koga, Yujiro Ueda, Azusa Komori, Satoshi Otsu …

Oncology 101(1) 22-31 2022年10月4日
A multicentre retrospective study comparing site-specific treatment with empiric treatment for unfavourable subset of cancer of unknown primary site

Kazuo Nishikawa, Shuichi Hironaka, Takashi Inagaki, Azusa Komori, Satoshi Otsu, Kenji Mitsugi, Akitaka Makiyama, Koichiro Watanabe, Shingo Tamura, Yuta Okumura …

Japanese Journal of Clinical Oncology 52(12) 1416-1422 2022年9月1日

もっとみる

MISC

A prospective study of FOLFIRI plus aflibercept as second-line treatment after failure of FOLFOXIRI plus bevacizumab in patients with unresectable/metastatic colorectal cancer (CRC): EFFORT study

Hironaga Satake, Koji Ando, Hisateru Yasui, Yuji Negoro, Tatsuya Kinjo, Koutarou Yuge, Kenji Baba, Hiroyuki Orita, Keiji Hirata, Mototsugu Shimokawa …

JOURNAL OF CLINICAL ONCOLOGY 41(16) 2023年6月1日
高齢者進行・再発胃癌に対するS-1+ラムシルマブ療法の多施設共同第II相試験(KSCC1701)

伊澤直樹, 陶山浩一, 勝屋弘雄, 小林和真, 上之園芳一, 胡慶江, 下川元継, 牧山明資, 佐伯浩司, 沖英次 …

日本癌治療学会学術集会抄録集 59回 O49-2 2021年10月
The randomized phase II study of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab as the first-line treatment in metastatic colorectal cancer with RAS wild-type tumors: The DEEPER trial (JACCRO CC-13).

Akihito Tsuji, Hisatsugu Ohori, Tatsuro Yamaguchi, Masato Matsuura, Atsujiro Nishioka, Akitaka Makiyama, Shingo Noura, Mitsugu Kochi, Tamotsu Sagawa, Masahito Kotaka …

JOURNAL OF CLINICAL ONCOLOGY 39(15) 2021年5月
A multicenter phase II study of S-1 plus ramucirumab as first-line treatment in elderly patients with advanced/recurrent gastric cancer (KSCC1701).

Hiroo Katsuya, Koichi Suyama, Kazuma Kobayashi, Naoki Izawa, Yoshikazu Uenosono, Qingjiang Hu, Tetsuya Kusumoto, Hajime Otsu, Hiroyuki Orita, Hirofumi Kawanaka …

JOURNAL OF CLINICAL ONCOLOGY 39(15) 2021年5月
Analysis of early tumor shrinkage (ETS) and depth of response (DpR) in metastatic colorectal cancer (mCRC) patients (pts) treated with second-line FOLFIRI plus panitumumab (Pani) or bevacizumab (Bev): Results from a randomized phase II WJOG6210G trial

Naoki Izawa, Kohei Shitara, Toshiki Masuishi, Tadamichi Denda, Kentaro Yamazaki, Toshikazu Moriwaki, Hiroyuki Okuda, Chihiro Kondoh, Tomohiro Nishina, Akitaka Makiyama …

JOURNAL OF CLINICAL ONCOLOGY 38(4) 2020年2月
Final results of multicenter phase Ib/ II study of biweekly trifluridine/tipiracil with bevacizumab combination for patients with mCRC refractory to standard therapies (BiTS study)

Masato Nakamura, Hironaga Satake, Koji Oba, Masahito Kotaka, Yoshinori Kagawa, Hisateru Yasui, Takanori Watanabe, Toshihiko Matsumoto, Takayuki Kii, Tetsuji Terazawa …

JOURNAL OF CLINICAL ONCOLOGY 38(4) 2020年2月
Multicenter phase Ib/II study of biweekly trifluridine/tipiracil with bevacizumab combination for patients with metastatic colorectal cancer refractory to standard therapies (BITS study).

Masahito Kotaka, Hironaga Satake, Koji Oba, Yoshinori Kagawa, Hisateru Yasui, Masato Nakamura, Takanori Watanabe, Toshihiko Matsumoto, Takayuki Kii, Tetsuji Terazawa …

JOURNAL OF CLINICAL ONCOLOGY 37(4) 2019年2月
トラスツズマブ不応HER2陽性進行・再発胃癌におけるHER2 status再評価(KSCC1604)

有上貴明, 佐伯浩司, 柏田知美, 牧山明資, 岩槻政晃, 成田有季哉, 佐竹悠良, 松田佳子, 園田英人, 下川元継 …

日本癌治療学会学術集会抄録集 56回 O58-6 2018年10月
Patient reported outcomes (PRO) results for prophylactic effect of dexamethasone on regorafenib-related fatigue and/or malaise: a randomized, placebo-controlled, double-blind clinical study in patients with unresectable metastatic colorectal cancer: KSCC1402/HGCSG1402.

Mototsugu Shimokawa, Eiji Oki, Takuhiro Yamaguchi, Hiroaki Tanioka, Yuji Miyamoto, Akihito Tsuji, Masako Asayama, Takeshi Shiraishi, Satoshi Yuki, Masahito Kotaka …

JOURNAL OF CLINICAL ONCOLOGY 36(15) 2018年5月
Biomarker study for trastuzumab continuation beyond progression in a randomized phase II trial of weekly paclitaxel +/- trastuzumab in patients with HER2-positive advanced gastric or gastro-esophageal junction cancer refractory to trastuzumab combined with fluoropyrimidine and platinum (WJOG7112G).

Yasutaka Sukawa, Akitaka Makiyama, Taito Esaki, Gen Hirano, Masato Komoda, Tomomi Kashiwada, Junji Kawada, Ayumu Hosokawa, Takashi Tsuda, Akihito Tsuji …

JOURNAL OF CLINICAL ONCOLOGY 36(15) 2018年5月
Analysis of RAS/BRAF mutations in a randomized phase II WJOG6510G study of panitumumab plus irinotecan versus cetuximab plus irinotecan in chemorefractory metastatic colorectal cancer.

Tomohiro Nishina, Hiroya Taniguchi, Daisuke Sakai, Hisato Kawakami, Naotoshi Sugimoto, Hiroki Hara, Taito Esaki, Tadamichi Denda, Akitaka Makiyama, Masahiro Tsuda …

JOURNAL OF CLINICAL ONCOLOGY 36(4) 2018年2月
Plasma ICAM-1 (pICAM-1) and plasma IL-8 (pIL-8) level as biomarker of metastatic colorectal cancer patients (mCRC) treated with mFOLFOX6/XELOX plus bevacizumab (BV) (WJOG7612GTR).

Yoshiyuki Yamamoto, Wataru Okamoto, Akitaka Makiyama, Kohei Shitara, Tadamichi Denda, Takashi Ogura, Yasuyuki Nakano, Tomohiro Nishina, Masato Komoda, Hiroki Hara …

JOURNAL OF CLINICAL ONCOLOGY 36(4) 2018年2月
70歳以上の結腸・直腸癌患者に対するTFTD(TAS-102)とBevacizumabの第II相臨床試験

沖英次, 佐伯浩司, 牧山明資, 中西良太, 掛地吉弘, 赤木由人, 馬場秀夫, 前原喜彦

日本癌治療学会学術集会抄録集 55回 SR-1 2017年10月
Approaches to cancer treatment in the elderly: Gastric cancer

Akitaka Makiyama

ANNALS OF ONCOLOGY 28 2017年10月
Dynamic changes in levels of gene mutations using circulating tumor DNA (ctDNA) and efficacy of 1st-line modified (m)-FOLFOXIRI plus bevacizumab (bev) for metastatic colorectal cancer (mCRC) harboring RAS mutation (mt) (JACCRO CC-11)

Y. Sunakawa, T. Sekikawa, J. Usher, H. Satake, Y. Jaimes, Y. Miyamoto, M. Nakamura, H. Nakayama, K. Kazama, A. Takagane …

ANNALS OF ONCOLOGY 28 2017年9月
Updated report: A randomized, double-blind, placebo-controlled phase II study of prophylactic dexamethasone (dex) therapy for fatigue and malaise due to regorafenib in patient (pts) with metastatic colorectal cancer (mCRC): (KSCC1402/HGCSG1402)

S. Yuki, Y. Komatsu, H. Satake, Y. Miyamoto, H. Tanioka, A. Tsuji, M. Asayama, T. Shiraishi, M. Kotaka, A. Makiyama …

ANNALS OF ONCOLOGY 27 2016年10月
TGF-beta regulates CD44 expression of cancer cells through epithelial-to-mesenchymal transition in malignant ascites

Michitaka Nakano, Mamoru Tanaka, Risa Tanaka, Akitaka Makiyama, Keita Uchino, Taito Esaki, Kenji Mitsuki, Eishi Baba

ANNALS OF ONCOLOGY 27 2016年7月
Trifluridine-tipiracil for multidrug-resistant advanced colorectal cancer: A multicenter retrospective study

Shuji Arita, Tsuyoshi Shirakawa, Yuzo Matsushita, Hozumi Kumagai, Gen Hirano, Akitaka Makiyama, Yoshihiro Shibata, Shingo Tamura, Hitoshi Kusaba, Eishi Baba

ANNALS OF ONCOLOGY 26 99-100 2015年11月
Multicenter retrospective analysis for elderly patients with advanced gastric cancer (AGC) received first-line chemotherapy in clinical practice.

Kenji Kunieda, Akitaka Makiyama, Masaaki Noguchi, Takeshi Kajiwara, Takao Tamura, Koji Takeda, Yasushi Tsuji, Keiko Minashi, Toshikazu Moriwaki, Naotoshi Sugimoto …

JOURNAL OF CLINICAL ONCOLOGY 33(15) 2015年5月
Exploratory analysis of a prognosis predictive formula for metastatic colorectal cancer treated with chemotherapy.

Mamoru Tanaka, Hitoshi Kusaba, Satomi Mukaide, Junji Kishimoto, Hozumi Kumagai, Akitaka Makiyama, Tsuyoshi Shirakawa, Hisanobu Oda, Masato Komoda, Kenji Mitsugi …

JOURNAL OF CLINICAL ONCOLOGY 33(3) 2015年1月

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牧山明資

基本情報

論文

MISC

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