makoto higuchi

J-GLOBAL         Last updated: Jun 23, 2019 at 11:35
 

Research Areas

 
 

Academic & Professional Experience

 
2019
 - 
Today
Department Head, Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
 

Published Papers

 
Terada T, Yokokura M, Obi T, Bunai T, Yoshikawa E, Ando I, Shimada H, Suhara T, Higuchi M, Ouchi Y
Journal of Neurology      Mar 2019   [Refereed]
Hattori Y, Aoyama K, Maeda J, Arimura N, Takahashi Y, Sasaki M, Fujinaga M, Seki C, Nagai Y, Kawamura K, Yamasaki T, Zhang MR, Higuchi M, Koike T
Journal of Medicinal Chemistry   62(5) 2362-2375   Mar 2019   [Refereed]
Takeuchi J, Kikukawa T, Saito H, Hasegawa I, Takeda A, Hatsuta H, Kawabe J, Wada Y, Mawatari A, Igesaka A, Doi H, Watanabe Y, Shimada H, Kitamura S, Higuchi M, Suhara T, Itoh Y
The Open Biomedical Engineering Journal   13 55-66   Mar 2019   [Refereed]
Endo H, Shimada H, Sahara N, Ono M, Koga S, Kitamura S, Niwa F, Hirano S, Kimura Y, Ichise M, Shinotoh H, Zhang MR, Kuwabara S, Dickson DW, Toda T, Suhara T, Higuchi M
Movement Disorders   34(5) 744-754   Mar 2019   [Refereed]
Tashima H, Yoshida E, Iwao Y, Wakizaka H, Maeda T, Seki C, Kimura Y, Takado Y, Higuchi M, Suhara T, Yamashita T, Yamaya T
Physics in Medicine & Biology   64(6) 065004   Mar 2019   [Refereed]
Ikeda A, Shimada H, Nishioka K, Takanashi M, Hayashida A, Li Y, Yoshino H, Funayama M, Ueno Y, Hatano T, Sahara N, Suhara T, Higuchi M, Hattori N
Movement Disorders   34(4) 568-574   Feb 2019   [Refereed]
Shinotoh H, Shimada H, Kokubo Y, Tagai K, Niwa F, Kitamura S, Endo H, Ono M, Kimura Y, Hirano S, Mimuro M, Ichise M, Sahara N, Zhang MR, Suhara T, Higuchi M
Neurology   92(2) e136-e147   Jan 2019   [Refereed]
Urushihata T, Takuwa H, Seki C, Tachibana Y, Takahashi M, Kershaw J, Takado Y, Aoki I, Higuchi M, Ito H, Obata T
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   17(4) 318-324   Oct 2018   [Refereed]
Chiotis K, Stenkrona P, Almkvist O, Stepanov V, Ferreira D, Arakawa R, Takano A, Westman E, Varrone A, Okamura N, Shimada H, Higuchi M, Halldin C, Nordberg A
European Journal of Nuclear Medicine and Molecular Imaging   45(9) 1605-1617   Jul 2018   [Refereed]
Perez-Soriano A, Matarazzo M, Vafai N, Shahinfard E, Miao Q, Higuchi M, Sossi V, Stoessl AJ
Movement Disorders   33(8) 1359-1360   Jun 2018   [Refereed]
Ito T, Kimura Y, Seki C, Ichise M, Yokokawa K, Kawamura K, Takahashi H, Higuchi M, Zhang MR, Suhara T, Yamada M
EJNMMI Research   8(1) 48   Jun 2018   [Refereed]
Kitamura S, Shimada H, Niwa F, Endo H, Shinotoh H, Takahata K, Kubota M, Takado Y, Hirano S, Kimura Y, Zhang MR, Kuwabara S, Suhara T, Higuchi M
Journal of Neurology, Neurosurgery, and Psychiatry   89(11) 1208-1214   Jun 2018   [Refereed]
Ni R, Ji B, Ono M, Sahara N, Zhang MR, Aoki I, Nordberg A, Suhara T, Higuchi M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   59(6) 960-966   Jun 2018   [Refereed]
Matsumoto G, Matsumoto K, Kimura T, Suhara T, Higuchi M, Sahara N, Mori N
International Journal of Molecular Science   19(5) E1497   May 2018   [Refereed]
Colás L, Domercq M, Ramos-Cabrer P, Palma A, Gómez-Vallejo V, Padro D, Plaza-García S, Pulagam KR, Higuchi M, Matute C, Llop J, Martín A
Glia      Mar 2018   [Refereed]
Barron AM, Ji B, Kito S, Suhara T, Higuchi M
The Biochemical journal   475(1) 75-85   Jan 2018   [Refereed]
Takenoshita N, Fukasawa R, Ogawa Y, Shimizu S, Umahara T, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H
Current Alzheimer Research   15(11) 1062-1069   2018   [Refereed]
Sahara N, Maeda J, Ishikawa A, Tokunaga M, Suhara T, Higuchi M
Journal of Alzheimer's Disease   64(s1) S353-S359   2018   [Refereed]
Goedert M, Yamaguchi Y, Mishra SK, Higuchi M, Sahara N
Frontiers in neurology   9 70   2018   [Refereed]
Ishikawa A, Tokunaga M, Maeda J, Minamihisamatsu T, Shimojo M, Takuwa H, Ono M, Ni R, Hirano S, Kuwabara S, Ji B, Zhang MR, Aoki I, Suhara T, Higuchi M, Sahara N
Journal of Alzheimer's disease : JAD   61(3) 1037-1052   2018   [Refereed]
Hirano S, Shinotoh H, Shimada H, Ota T, Sato K, Tanaka N, Zhang MR, Higuchi M, Fukushi K, Irie T, Kuwabara S, Suhara T
Journal of Alzheimer's Disease   62(4) 1539-1548   2018   [Refereed]
Lemoine L, Gillberg PG, Svedberg M, Stepanov V, Jia Z, Huang J, Nag S, Tian H, Ghetti B, Okamura N, Higuchi M, Halldin C, Nordberg A
Alzheimer's research & therapy   9(1) 96   Dec 2017   [Refereed]
Moriguchi S, Takano H, Kimura Y, Nagashima T, Takahata K, Kubota M, Kitamura S, Ishii T, Ichise M, Zhang MR, Shimada H, Mimura M, Meyer JH, Higuchi M, Suhara T
The international journal of neuropsychopharmacology   20(12) 957-962   Dec 2017   [Refereed]
Mori W, Takei M, Furutsuka K, Fujinaga M, Kumata K, Muto M, Ohkubo T, Hashimoto H, Tamagnan G, Higuchi M, Kawamura K, Zhang MR
Nuclear medicine and biology   55 12-18   Dec 2017   [Refereed]
Tsunoda K, Yamashita T, Shimada H, Nomura E, Takahashi Y, Shang J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Higuchi M, Suhara T, Kokubo Y, Kuzuhara S, Abe K
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   46 64-67   Dec 2017   [Refereed]
Pulagam KR, Colás L, Padro D, Plaza-García S, Gómez-Vallejo V, Higuchi M, Llop J, Martín A
EJNMMI research   7(1) 93   Nov 2017   [Refereed]
Kubota M, Nagashima T, Takano H, Kodaka F, Fujiwara H, Takahata K, Moriguchi S, Kimura Y, Higuchi M, Okubo Y, Takahashi H, Ito H, Suhara T
The international journal of neuropsychopharmacology   20(11) 928-935   Nov 2017   [Refereed]
Koga K, Nagai Y, Hanyu M, Yoshinaga M, Chaki S, Ohtake N, Ozaki S, Zhang MR, Suhara T, Higuchi M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   58(10) 1652-1658   Oct 2017   [Refereed]
Takahata K, Kimura Y, Seki C, Tokunaga M, Ichise M, Kawamura K, Ono M, Kitamura S, Kubota M, Moriguchi S, Ishii T, Takado Y, Niwa F, Endo H, Nagashima T, Ikoma Y, Zhang MR, Suhara T, Higuchi M
EJNMMI research   7(1) 63   Aug 2017   [Refereed]
Higuchi M
Brain and nerve = Shinkei kenkyu no shinpo   69(7) 819-823   Jul 2017   [Refereed]
Perez-Soriano A, Arena JE, Dinelle K, Miao Q, McKenzie J, Neilson N, Puschmann A, Schaffer P, Shinotoh H, Smith-Forrester J, Shahinfard E, Vafai N, Wile D, Wszolek Z, Higuchi M, Sossi V, Stoessl AJ
Movement disorders : official journal of the Movement Disorder Society   32(7) 1016-1024   Jul 2017   [Refereed]
Koga S, Ono M, Sahara N, Higuchi M, Dickson DW
Movement disorders : official journal of the Movement Disorder Society   32(6) 884-892   Jun 2017   [Refereed]
Suhara T, Chaki S, Kimura H, Furusawa M, Matsumoto M, Ogura H, Negishi T, Saijo T, Higuchi M, Omura T, Watanabe R, Miyoshi S, Nakatani N, Yamamoto N, Liou SY, Takado Y, Maeda J, Okamoto Y, Okubo Y, Yamada M, Ito H, Walton NM, Yamawaki S
The international journal of neuropsychopharmacology   20(4) 285-294   Apr 2017   [Refereed]
Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, Zhang MR, Higuchi M
Brain : a journal of neurology   140(3) 764-780   Mar 2017   [Refereed]
Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JÁ, Cilia R, Ballanger B, Niethammer M, Stoessl JA, IPMDS-Neuroimaging Study Group.
Movement disorders : official journal of the Movement Disorder Society   32(2) 181-192   Feb 2017   [Refereed]
Shimozawa A, Ono M, Takahara D, Tarutani A, Imura S, Masuda-Suzukake M, Higuchi M, Yanai K, Hisanaga SI, Hasegawa M
Acta neuropathologica communications   5(1) 12   Feb 2017   [Refereed]
Sahara N, Shimojo M, Ono M, Takuwa H, Febo M, Higuchi M, Suhara T
Frontiers in neurology   8 663   2017   [Refereed]
Takahashi M, Urushihata T, Takuwa H, Sakata K, Takado Y, Shimizu E, Suhara T, Higuchi M, Ito H
Frontiers in neuroscience   11 723   2017   [Refereed]
Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T
PloS one   12(12) e0189318   2017   [Refereed]
Shimada H, Kitamura S, Shinotoh H, Endo H, Niwa F, Hirano S, Kimura Y, Zhang MR, Kuwabara S, Suhara T, Higuchi M
Alzheimer's & dementia (Amsterdam, Netherlands)   6 11-20   2017   [Refereed]
Kimura Y, Endo H, Ichise M, Shimada H, Seki C, Ikoma Y, Shinotoh H, Yamada M, Higuchi M, Zhang MR, Suhara T
EJNMMI research   6(1) 24   Dec 2016   [Refereed]
Koga K, Maeda J, Tokunaga M, Hanyu M, Kawamura K, Ohmichi M, Nakamura T, Nagai Y, Seki C, Kimura Y, Minamimoto T, Zhang MR, Fukumura T, Suhara T, Higuchi M
EJNMMI research   6(1) 11   Dec 2016   [Refereed]
Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T
Nature communications   7 13605   Dec 2016   [Refereed]
Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M
The Journal of neuroscience : the official journal of the Society for Neuroscience   36(45) 11544-11558   Nov 2016   [Refereed]
Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, Suhara T, Higuchi M, Inoue H
Scientific reports   6 34904   Oct 2016   [Refereed]
Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang MR, Suhara T
European journal of nuclear medicine and molecular imaging   43(9) 1653-1663   Aug 2016   [Refereed]
Barron AM, Tokunaga M, Zhang MR, Ji B, Suhara T, Higuchi M
Journal of neuroinflammation   13(1) 221   Aug 2016   [Refereed]
Lacivita E, Stama ML, Maeda J, Fujinaga M, Hatori A, Zhang MR, Colabufo NA, Perrone R, Higuchi M, Suhara T, Leopoldo M
Chemistry & biodiversity   13(7) 875-883   Jul 2016   [Refereed]
Koga K, Yoshinaga M, Uematsu Y, Nagai Y, Miyakoshi N, Shimoda Y, Fujinaga M, Minamimoto T, Zhang MR, Higuchi M, Ohtake N, Suhara T, Chaki S
The Journal of pharmacology and experimental therapeutics   357(3) 495-508   Jun 2016   [Refereed]
Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MÁ, Martín A, Lizasoain I
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   36(4) 702-708   Apr 2016   [Refereed]

Misc

 
樋口真人
Bio Clinica   33(14) 1331‐1335   Dec 2018
タウタンパク病変を可視化する技術の開発
樋口 真人
アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発   224-237   Aug 2018   [Invited]
堀口 隆司, 樋口 真人, 須原 哲也
臨床精神薬理   21(2) 169-181   Feb 2018
樋口真人
和光純薬時報   86(1) 8‐11   Jan 2018
武田 寛史, 須貸 拓馬, 田桑 弘之, 季 斌, 佐原 成彦, 須原 哲也, 樋口 真人, 冨田 裕, 鈴木 則宏, 菅野 巖, 正本 和人
レーザー学会研究会報告 = Reports the on topical meeting of the Laser Society of Japan   17(25) 21-25   Oct 2017
前田純, 樋口真人, 須原哲也
臨床精神薬理   20(9) 1003‐1010   Sep 2017
前田 純, 樋口 真人, 須原 哲也
臨床精神薬理   20(9) 1003-1010   Sep 2017
樋口真人
Brain and Nerve   69(7) 0819‐0823   Jul 2017

Conference Activities & Talks

 
Visualization of proteinopathies in Alzheimer's disease and allied neurodegenerative disorders [Invited]
Makoto Higuchi
KSCPT-JSCPT Joint Symposium   16 Nov 2018   Korean Society for Clinical Pharmacology and Therapeutics
A major neuropathological characteristic of age-associated neurodegenerative dementia represented by Alzheimer’s disease (AD) is deposition of aggregated proteins in the brain as a hallmark lesion. Amyloid-β plaques and tau tangles accumulate in A...
新規モノアシルグリセロールリパーゼPETリガンド[18F]T-401の前臨床評価
関 千江, 服部 靖志, 前田 純, 永井 裕司, 内田 翔子, 徳永 正希, 張 明栄, 小池竜樹, 樋口 真人
第58回日本核医学会学術総会に参加し武田薬品との共同研究成果を発表   15 Nov 2018   社団法人日本核医学会
Introduction Monoacylglycerol lipase (MAGL) is considered as a novel therapeutic target of CNS disorders. [18F]T-401 has been developed as a reversible and selective PET imaging agent. The aim of this study was to test the capability of [18F]T-401...
Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain
Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa, Masayuki Fujinaga, Tatsuya Kikuchi, Maki Okada, Koki Mimura, Yuji Nagai, Chie Seki, Masaki Tokunaga, Jun Maeda, Yuhei Takado, Manami Takahashi, Takeharu Minamihisamatsu, Ming-Rong Zhang, Yutaka Tomita, Norihiro Suzuki, Takafumi Minamimoto, Anton Maximov, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
SfN2018   7 Nov 2018   Society for Neuroscience
Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain
Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa, Masayuki Fujinaga, Tatsuya Kikuchi, Maki Okada, Koki Mimura, Yuji Nagai, Chie Seki, Masaki Tokunaga, Jun Maeda, Yuhei Takado, Manami Takahashi, Takeharu Minamihisamatsu, Ming-Rong Zhang, Yutaka Tomita, Norihiro Suzuki, Takafumi Minamimoto, Anton Maximov, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
International Meeting on Bioimaging for Young Researchers   29 Oct 2018   新学術レゾナンスバイオ
Imaging Molecular Pathologies of Alzheimer’s Disease and Related Neurodegenerative Disorders [Invited]
樋口 真人
International Alzheimer’s Disease Conferenceにて講演および研究打ち合わせ   8 Sep 2018   Hong Kong Science & Technology Parks Corporation
各種タウ疾患(アルツハイマー病、前頭側頭葉変性症など)の中核病変を可視化するPET薬剤の特性について解説する。

Patents

 
特願2015-547591 : [11C] AND [18f] LABELED 1,3-DIPHENYL-5-(PYRIMIDIN-2-YL)-PYRIDIN-2(1 h)-ONE DERIVATIVES AND THEIR USE FOR PET IMAGING OF THE AMPA RECEPTOR
Norihito Oi , Noboru Yamamoto , Michiyuki Suzuki , Yosuke Nakatani , Tetsuya Suhara , Ming-Rong Zhang , Toshimitsu Fukumura , Makoto Higuchi , Takafumi Minamimoto , Jun Maeda , Masaki Tokunaga , Yuji Nagai
We found some compounds with high affinity for AMPA receptors, and labeled these compounds. As a result, these compounds were found to be potentially useful as PET probes for AMPA receptor.
Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Ming-Rong Zhang, Hitoshi Shimada
EP2767532 B1 : NOVEL COMPOUND FOR IMAGING TAU PROTEIN ACCUMULATED IN THE BRAIN
Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Ming-Rong Zhang, Hitoshi Shimada
PCT/JP2014/060233 : [11C] AND [18f] LABELED 1,3-DIPHENYL-5-(PYRIMIDIN-2-YL)-PYRIDIN-2(1 h)-ONE DERIVATIVES AND THEIR USE FOR PET IMAGING OF THE AMPA RECEPTOR
Norihito Oi , Noboru Yamamoto , Michiyuki Suzuki , Yosuke Nakatani , Tetsuya Suhara , Ming-Rong Zhang , Toshimitsu Fukumura , Makoto Higuchi , Takafumi Minamimoto , Jun Maeda , Masaki Tokunaga , Yuji Nagai
We found some compounds with high affinity for AMPA receptors, and labeled these compounds. As a result, these compounds were found to be potentially useful as PET probes for AMPA receptor.
2012397435 : NOVEL COMPOUND FOR IMAGING TAU PROTEIN ACCUMULATED IN THE BRAIN
Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Ming-Rong Zhang, Hitoshi Shimada