論文

査読有り
2021年2月

A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light

Science Advances
  • Osamu Kutomi
  • Ryosuke Yamamoto
  • Keiko Hirose
  • Katsutoshi Mizuno
  • Yuuhei Nakagiri
  • Hiroshi Imai
  • Akira Noga
  • Jagan Mohan Obbineni
  • Noemi Zimmermann
  • Masako Nakajima
  • Daisuke Shibata
  • Misa Shibata
  • Kogiku Shiba
  • Masaki Kita
  • Hideo Kigoshi
  • Yui Tanaka
  • Yuya Yamasaki
  • Yuma Asahina
  • Chihong Song
  • Mami Nomura
  • Mamoru Nomura
  • Ayako Nakajima
  • Mia Nakachi
  • Lixy Yamada
  • Shiori Nakazawa
  • Hitoshi Sawada
  • Kazuyoshi Murata
  • Kaoru Mitsuoka
  • Takashi Ishikawa
  • Ken-ichi Wakabayashi
  • Takahide Kon
  • Kazuo Inaba
  • 全て表示

7
9
開始ページ
eabf3621
終了ページ
eabf3621
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/sciadv.abf3621
出版者・発行元
American Association for the Advancement of Science (AAAS)

Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. <italic>Chlamydomonas</italic> lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.

リンク情報
DOI
https://doi.org/10.1126/sciadv.abf3621
URL
https://syndication.highwire.org/content/doi/10.1126/sciadv.abf3621
ID情報
  • DOI : 10.1126/sciadv.abf3621
  • ISSN : 2375-2548
  • eISSN : 2375-2548

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