2021年2月
A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
Science Advances
- 巻
- 7
- 号
- 9
- 開始ページ
- eabf3621
- 終了ページ
- eabf3621
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/sciadv.abf3621
- 出版者・発行元
- American Association for the Advancement of Science (AAAS)
Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. <italic>Chlamydomonas</italic> lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.
- リンク情報
- ID情報
-
- DOI : 10.1126/sciadv.abf3621
- ISSN : 2375-2548
- eISSN : 2375-2548