論文

2012年5月

Enhancement of cumulative photoirradiated and ac magnetic-field induced cancer (HeLa) cell killing efficacy of mixed α and γ-Fe <inf>2</inf>O<inf>3</inf> magnetic nanoparticles

New Journal of Chemistry
  • Md Shariful Islam
  • ,
  • Yoshihumi Kusumoto
  • ,
  • Md Abdulla-Al-Mamun
  • ,
  • Yuji Horie
  • ,
  • Hirotaka Manaka

36
5
開始ページ
1201
終了ページ
1209
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c2nj40029d
出版者・発行元
ROYAL SOC CHEMISTRY

In this current study we synthesized mixed α and γ-Fe O nanoparticles and their synergistic toxic effect against HeLa cells was investigated under ac (alternating current) magnetic-field induction and photoirradiation conditions at room temperature. The experiment was designed to find out the cancer cell killing efficacy of as-synthesized bare γ-Fe O , bare α-Fe O and mixed α and γ-Fe O nanoparticles under combined ac magnetic-field induction and photoirradiation conditions. The toxic effect of nanoparticles was obtained by counting the percentage of viable cells after all the treatments were completed using various concentrations. The results revealed that the highest toxic effect was obtained using mixed α and γ-Fe O nanoparticles under combined ac magnetic-field induction and photoirradiation conditions at a dose of 60 μg mL MEM (minimum essential medium), i.e., approximately 98% cancer cells were killed, whereas under only ac magnetic-field induction or only photoirradiation conditions, only 89% and 66% cancer cells were destroyed using the same dose of same nanomaterials, respectively. We also noticed that 55% and 79% cancer cells were destroyed using bare α-Fe O and bare γ-Fe O nanoparticles, respectively, under combined ac magnetic-field induction and photoirradiation conditions using the same dose. To the best of our understanding, the mechanism or reason for almost 100% HeLa cell killing under the combined conditions can be ascribed to the combined or additive effect of ac magnetic-field induced hyperthermia and photocatalytic cytotoxicity. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012. 2 3 2 3 2 3 2 3 2 3 2 3 2 3 -1

リンク情報
DOI
https://doi.org/10.1039/c2nj40029d
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201202206202873540
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303067500011&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861447915&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84861447915&origin=inward
ID情報
  • DOI : 10.1039/c2nj40029d
  • ISSN : 1144-0546
  • eISSN : 1369-9261
  • J-Global ID : 201202206202873540
  • SCOPUS ID : 84861447915
  • Web of Science ID : WOS:000303067500011

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