論文

国際誌
2019年1月9日

Bivalent Human Papillomavirus Vaccine Effectiveness in a Japanese Population: High Vaccine-Type-Specific Effectiveness and Evidence of Cross-Protection.

The Journal of infectious diseases
  • Risa Kudo
  • ,
  • Manako Yamaguchi
  • ,
  • Masayuki Sekine
  • ,
  • Sosuke Adachi
  • ,
  • Yutaka Ueda
  • ,
  • Etsuko Miyagi
  • ,
  • Megumi Hara
  • ,
  • Sharon J B Hanley
  • ,
  • Takayuki Enomoto

219
3
開始ページ
382
終了ページ
390
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/infdis/jiy516

Background: Proactive recommendations for human papillomavirus (HPV) vaccines in Japan have been suspended for 5 years because of safety concerns. While no scientific evidence exists to substantiate these concerns, one reason given for not reinstating recommendations is the lack of reliable vaccine effectiveness (VE) data in a Japanese population. This study reports the VE of the bivalent HPV vaccine in Japanese women aged 20-22 years. Methods: During cervical screening between 2014 and 2016, women had Papanicolaou smears and HPV tests performed and provided data about their sexual history. Estimates of VE for vaccine-targeted HPV type 16 (HPV16) and 18 and cross-protection against other types were calculated. Results: Overall, 2197 women were tested, and 1814 were included in the analysis. Of these, 1355 (74.6%) were vaccinated, and 1295 (95.5%) completed the 3-dose schedule. In women sexually naive at vaccination, the pooled VEs against HPV16 and 18 and for HPV31, 45, and 52 were 95.5% (P < .01) and 71.9% (P < .01), respectively. When adjusted for number of sex partners and birth year, pooled VEs were 93.9% (P = .01) and 67.7% (P = .01) for HPV16 and 18 and HPV31, 45, and 52, respectively. Conclusions: The bivalent HPV vaccine is highly effective against HPV16 and 18. Furthermore, significant cross-protection against HPV31, 45, and 52 was demonstrated and sustained up to 6 years after vaccination. These findings should reassure politicians about the VE of bivalent HPV vaccine in a Japanese population.

リンク情報
DOI
https://doi.org/10.1093/infdis/jiy516
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30299519
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325350
ID情報
  • DOI : 10.1093/infdis/jiy516
  • PubMed ID : 30299519
  • PubMed Central 記事ID : PMC6325350

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