論文

査読有り 国際誌
2017年9月29日

Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome.

Scientific reports
  • Michiko Kano
  • Tomohiko Muratsubaki
  • Lukas Van Oudenhove
  • Joe Morishita
  • Makoto Yoshizawa
  • Keiji Kohno
  • Mao Yagihashi
  • Yukari Tanaka
  • Shunji Mugikura
  • Patrick Dupont
  • Huynh Giao Ly
  • Kei Takase
  • Motoyori Kanazawa
  • Shin Fukudo
  • 全て表示

7
1
開始ページ
12425
終了ページ
12425
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-017-09635-x
出版者・発行元
NATURE PUBLISHING GROUP

Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic-pituitary-adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects. Male IBS patients had greater increases in colonic motility than male HCs after CRH. Female IBS patients showed altered sympathovagal balance and lower basal parasympathetic tone relative to female control subjects. Brain responses to rectal distention were measured in the same subjects using functional magnetic resonance imaging, and their associations with individual ACTH responses to CRH were tested. A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients. Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH. Centrally acting treatments may dampen the stress induced physical symptoms in IBS.

リンク情報
DOI
https://doi.org/10.1038/s41598-017-09635-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28963545
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622133
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000412032000034&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/s41598-017-09635-x
  • ISSN : 2045-2322
  • PubMed ID : 28963545
  • PubMed Central 記事ID : PMC5622133
  • Web of Science ID : WOS:000412032000034

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