Shun-ichi Wada

J-GLOBAL         Last updated: Nov 8, 2018 at 13:14
 
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Name
Shun-ichi Wada
Affiliation
Osaka University of Pharmaceutical Sciences
Research funding number
30278593

Research Areas

 
 

Published Papers

 
Junsuke Hayashi, Misa Nishigaki, Yosuke Ochi, Shun ichi Wada, Fumito Wada, Fumito Wada, Osamu Nakagawa, Satoshi Obika, Mariko Harada-Shiba, Hidehito Urata
Bioorganic and Medicinal Chemistry Letters   28 2171-2174   Jul 2018
© 2018 Elsevier Ltd Small interfering RNAs (siRNAs) are an active agent to induce gene silencing and they have been studied for becoming a biological and therapeutic tool. Various 2′-O-modified RNAs have been extensively studied to improve the nuc...
Mitsuaki Yamashita, Teruyuki Tahara, Shinya Hayakawa, Hironobu Matsumoto, Shun ichi Wada, Kiyoshi Tomioka, Akira Iida
Bioorganic and Medicinal Chemistry   26 1920-1928   May 2018
© 2018 Elsevier Ltd HDAC inhibitors enable histones to maintain a high degree of acetylation. The resulting looser state of chromatin DNA may increase the accessibility of DNA drug targets and consequently improve the efficiency of anticancer drug...
Shun ichi Wada, Anna Takesada, Yurie Nagamura, Eri Sogabe, Rieko Ohki, Junsuke Hayashi, Hidehito Urata
Bioorganic and Medicinal Chemistry Letters   27 5378-5381   Dec 2017
© 2017 Elsevier Ltd The conjugation of Aib-containing amphipathic helical peptide with cyclo(-Arg-Gly-Asp-D-Phe-Cys-) (cRGDfC) at the C-terminus of the helix peptide (PI) has been reported to be useful for constructing a carrier for targeted siRNA...
Junsuke Hayashi, Yusuke Samezawa, Yosuke Ochi, Shun ichi Wada, Hidehito Urata
Bioorganic and Medicinal Chemistry Letters   27 3135-3138   Jan 2017
© 2017 Elsevier Ltd We synthesized prodrug-type phosphotriester (PTE) oligonucleotides containing the six-membered cyclic disulfide moiety by using phosphoramidite chemistry. Prodrug-type oligonucleotides named “Reducing-Environment-Dependent Unca...
Hironobu Matsumoto, Mitsuaki Yamashita, Teruyuki Tahara, Shinya Hayakawa, Shun ichi Wada, Kiyoshi Tomioka, Akira Iida
Bioorganic and Medicinal Chemistry   25 4133-4144   Jan 2017
© 2017 Elsevier Ltd We developed novel nucleoside-based topoisomerase II selective inhibitors and showed that small structural units, such as catechols, are essential for DNA topoisomerase II inhibitory activity. Moreover, nucleoside analogues con...
Shun ichi Wada, Masashi Iwata, Yuka Ozaki, Takashi Ozaki, Junsuke Hayashi, Hidehito Urata
Bioorganic and Medicinal Chemistry   24 4478-4485   Jan 2016
© 2016 Elsevier Ltd To achieve the targeted delivery of siRNA, five conjugates of Aib-containing amphipathic helical peptides with mono-, di-, and trivalent cRGDfC [cyclo(-Arg-Gly-Asp-D-Phe-Cys-)], which is known to bind to αVβ3integrin, at severa...
Yosuke Ochi, Mieko Imai, Osamu Nakagawa, Osamu Nakagawa, Junsuke Hayashi, Shun Ichi Wada, Hidehito Urata
Bioorganic and Medicinal Chemistry Letters   26 845-848   Jan 2016
© 2015 Elsevier Ltd. All rights reserved. RNAs bearing various 2′-modifications have been synthesized in an effort to improve nuclease resistance. However, the gene silencing activity of small interfering RNAs (siRNAs) has been decreased or someti...
Junsuke Hayashi, Tomoko Hamada, Ikumi Sasaki, Osamu Nakagawa, Osamu Nakagawa, Shun Ichi Wada, Hidehito Urata
Bioorganic and Medicinal Chemistry Letters   25 3610-3615   Aug 2015
© 2015 Elsevier Ltd. A spermine-conjugated ethyl phosphotriester oligonucleotide was obtained by solid-phase synthesis based on phosphoramidite chemistry. The ethyl phosphotriester linkage was robust to exonuclease digestion and stable in fetal bo...
Yosuke Ochi, Osamu Nakagawa, Osamu Nakagawa, Junsuke Hayashi, Shun ichi Wada, Hidehito Urata, Hidehito Urata
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]   62    Jan 2015
Copyright © 2015 John Wiley & Sons, Inc. This unit describes the synthesis of 2'-O-methyldithiomethyluridine-containing oligonucleotides, which can be deprotected to yield the parental oligoribonucleotides under high concentrations of glutathion...
Shun Ichi Wada, Tomoe Urase, Yuka Hasegawa, Kenta Ban, Aya Sudani, Yui Kawai, Junsuke Hayashi, Hidehito Urata
Bioorganic and Medicinal Chemistry   22 6776-6780   Dec 2014
© 2014 Elsevier Ltd. All rights reserved. α-Aminoisobutyric acid (Aib)-containing peptide analogs derived from TV-XIIa, a cell-penetrating peptide (CPP), were synthesized to explore structure-activity relationships. The replacement of Aib at posit...