論文

査読有り
2014年4月

Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

METABOLISM-CLINICAL AND EXPERIMENTAL
  • Kumpei Tanisawa
  • ,
  • Hirokazu Taniguchi
  • ,
  • Xiaomin Sun
  • ,
  • Tomoko Ito
  • ,
  • Zhen-Bo Cao
  • ,
  • Shizuo Sakamoto
  • ,
  • Mitsuru Higuchi

63
4
開始ページ
574
終了ページ
583
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.metabol.2014.01.005
出版者・発行元
W B SAUNDERS CO-ELSEVIER INC

Objective. This cross-sectional study analyzed the association of serum irisin concentrations with cardiorespiratory fitness levels and common single nucleotide polymorphisms (SNPs) in the FNDC5 gene and examined the relationships between cardiorespiratory fitness levels, common SNPs in FNDC5, and glucose metabolism.
Materials/Methods. Cardiorespiratory fitness was assessed by measuring peak oxygen uptake (VO(2)peak) and serum irisin levels by ELISA in 163 Japanese men (age, 21-79 years). Subjects were divided into low- and high-fitness groups within each age group according to the median VO(2)peak value. Common SNPs (rs3480 and rs16835198) of the FNDC5 gene were genotyped with the TaqMan assay. Glucose metabolism was evaluated by measuring HbA1c, fasting plasma glucose (FPG), insulin levels, and HOMA-IR.
Results. Serum irisin levels were negatively correlated with age (p <0.001) and not associated with the VO(2)peak or HOMA-IR. In the low-fitness group, SNP analysis revealed that subjects with the rs3480 AG and GG genotypes had higher levels of insulin and HOMA-IR than those with the AA genotype (p <0.01; no significant difference was observed in the high-fitness group). The GG genotypes of rs16835198 were associated with increased HbA1c and FPG in the low-fitness group only (p <0.05). SNPs and both fitness groups were not associated with serum irisin levels.
Conclusions. In Japanese men, cardiorespiratory fitness levels and common SNPs in FNDC5 are not associated with circulating irisin levels, whereas high cardiorespiratory fitness abolishes the association between the rs3480 and rs16835198 SNPs and glucose metabolism independent of serum irisin levels. (C) 2014 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.metabol.2014.01.005
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24559842
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000333659300016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.metabol.2014.01.005
  • ISSN : 0026-0495
  • eISSN : 1532-8600
  • PubMed ID : 24559842
  • Web of Science ID : WOS:000333659300016

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