Papers

6 2008

Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers

AMINO ACIDS
  • Z. Zhao
  • ,
  • H. Satsu
  • ,
  • M. Fujisawa
  • ,
  • M. Hori
  • ,
  • Y. Ishimoto
  • ,
  • M. Totsuka
  • ,
  • A. Nambu
  • ,
  • S. Kakuta
  • ,
  • H. Ozaki
  • ,
  • M. Shimizu

Volume
35
Number
1
First page
217
Last page
224
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1007/s00726-007-0562-8
Publisher
SPRINGER

The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated. C57BL/6 female mice were given 3% DSS in drinking water for 5 d to induce acute colitis. Taurine at 2% was added to the drinking water 5 d before and during the DSS-treatment to investigate its preventive effect. Taurine supplementation significantly attenuated the weight decrease, diarrhea severity, colon shortening, and the increase in the colonic tissue myeloperoxidase activity induced by DSS. Taurine also significantly inhibited the increase in the expression of a pro-inflammatory chemokine, macrophage inflammatory protein 2 (MIP-2), but not of interleukin (IL)-1 beta or tumor necrosis factor (TNF)-alpha mRNA. Furthermore, taurine significantly protected the intestinal Caco-2 cell monolayers from the damage by macrophage-like THP-1 cells in an in vitro coculture system. These results suggest that taurine prevented DSS-induced colitis partly in association with (1) its inhibitory effects on the secretion of MIP-2 from the intestinal epithelial cells and on the infiltration of such inflammatory cells as neutrophils and (2) its cytoprotective functions on the epithelial barrier from the direct toxicity of DSS and from the inflammatory cell-induced injury.

Web of Science ® Times Cited Count : 22
View Related Records® in Web of Science ®

Link information
DOI
https://doi.org/10.1007/s00726-007-0562-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17619120
Scopus
https://www.scopus.com/record/display.uri?eid=2-s2.0-44849099640&origin=inward
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000256475700027&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=44849099640&origin=inward

Export
BibTeX RIS