Masatomo Takahashi - My portal

Profile Information

Affiliation: Assistant Professor, Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University

Researcher number: 30844419
ORCID ID: https://orcid.org/0000-0002-2493-2684
J-GLOBAL ID: 202201008850422542
researchmap Member ID: R000044675

Research Interests

Research History

Apr, 2022 - Present

助教, メタボロミクス分野, 九州大学生体防御医学研究所
Oct, 2018 - Mar, 2022

学術研究員 (特任助教), メタボロミクス分野, 九州大学生体防御医学研究所
Apr, 2016 - Oct, 2018

メタボロミクス分野, 九州大学生体防御医学研究所
Sep, 2014 - Mar, 2016

新事業支援課, 公益財団法人宮崎県産業振興機構研究専門員
Apr, 2010 - Jul, 2014

主任技師, 廃棄物・リサイクル, 香川県環境保健研究センター

Education

Oct, 2014 - Sep, 2017

Graduate School of Engineering, Osaka University
Apr, 2008 - Mar, 2010

生命先端工学専攻, 工学研究科, 大阪大学大学院
Apr, 2004 - Mar, 2008

School of Engineering, Osaka University

Papers

Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28

Takuya Morikawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kosei Moriyama, Gohsuke Hattori, Ryuta Fujioka, Shiroh Miura, Hiroki Shibata

Biomedicines, Apr 4, 2023
Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line.

Mayuko Yoda, Rin Mizuno, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Shinpei Kawaoka

Journal of biochemistry, Apr 4, 2023
Structural Analysis of Intracellular Lipid Radicals by LC/MS/MS Using a BODIPY-Based Profluorescent Nitroxide Probe.

Takumi Udo, Yuta Matsuoka, Masatomo Takahashi, Yoshihiro Izumi, Kota Saito, Kaho Tazoe, Moe Tanaka, Hideto Naka, Takeshi Bamba, Ken-Ichi Yamada

Analytical chemistry, Feb 27, 2023
Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.

Naoya Nishimura, Noriyuki Tomiyasu, Shota Torigoe, Satoru Mizuno, Hanako Fukano, Eri Ishikawa, Harutaka Katano, Yoshihiko Hoshino, Kazuhiro Matsuo, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Koichi Akashi, Sho Yamasaki

Tuberculosis (Edinburgh, Scotland), 138 102294-102294, Dec 13, 2022
Unified-hydrophilic-interaction/anion-exchange liquid chromatography mass spectrometry (unified-HILIC/AEX/MS): A single-run method for comprehensive and simultaneous analysis of polar metabolome.

Kohta Nakatani, Yoshihiro Izumi*, Masatomo Takahashi, Takeshi Bamba*

Analytical Chemistry, 94(48) 16877-16866, Dec, 2022 Peer-reviewed
Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.

Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki

Nature communications, 13(1) 6948-6948, Nov 14, 2022
PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy.

Keiko Morita, Mariko Wada, Kohta Nakatani, Yuki Matsumoto, Nahoki Hayashi, Ikuko Yamahata, Kotone Mitsunari, Nagi Mukae, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Michiko Shirane*

iScience, 25(12) 105612-105612, Nov, 2022 Peer-reviewed
Change in fatty acid composition of plasma triglyceride caused by a 2 week comprehensive risk management for diabetes: A prospective observational study of type 2 diabetes patients with supercritical fluid chromatography/mass spectrometry-based semi-target lipidomic analysis.

Naohiro Taya, Naoto Katakami, Kazuo Omori, Shigero Hosoe, Hirotaka Watanabe, Mitsuyoshi Takahara, Kazuyuki Miyashita, Hitoshi Nishizawa, Yutaka Konya, Sachiko Obara, Ayako Hidaka, Motonao Nakao, Masatomo Takahashi, Yoshihiro Izumi, Iichiro Shimomura, Takeshi Bamba

Journal of diabetes investigation, Oct 8, 2022
In-Needle Pre-Column Derivatization for Amino Acid Quantification (iPDAQ) Using HPLC.

Yuki Soma, Yoshihiro Izumi, Takehiko Shimohira, Masatomo Takahashi, Yuri Imado, Saki Tominaga, Kanako Tokito, Kosuke Hata, Shoji Shinadama, Mana Oshiro, Yoshihiro Hayakawa, Takeshi Bamba

Metabolites, 12(9), Aug 28, 2022
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.

Rin Mizuno, Hiroaki Hojo, Masatomo Takahashi, Soshiro Kashio, Sora Enya, Motonao Nakao, Riyo Konishi, Mayuko Yoda, Ayano Harata, Junzo Hamanishi, Hiroshi Kawamoto, Masaki Mandai, Yutaka Suzuki, Masayuki Miura, Takeshi Bamba, Yoshihiro Izumi, Shinpei Kawaoka

Nature communications, 13(1) 3346-3346, Jun 15, 2022
SGLT2阻害薬が肥満糖尿病マウスの骨格筋代謝に与える影響の検討

中村慎太郎, 横溝久, 大塚裕子, 和泉自泰, 高橋政友, 佐藤直市, 坂本竜一, 宮地康高, 宮澤崇, 馬場健史, 小川佳宏

糖尿病, 65(Suppl.1) S-184, Apr, 2022
Investigation of supercritical fluid chromatography retention behaviors using quantitative structure-retention relationships.

Le Si-Hung, Yoshihiro Izumi, Motonao Nakao, Masatomo Takahashi, Takeshi Bamba

Analytica chimica acta, 1197 339463-339463, Mar 8, 2022
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.

Shintaro Mise, Akinobu Matsumoto, Keisuke Shimada, Toshiaki Hosaka, Masatomo Takahashi, Kazuya Ichihara, Hideyuki Shimizu, Chisa Shiraishi, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Toru Ide, Yoshihiro Izumi, Takeshi Bamba, Tomomi Kimura-Someya, Mikako Shirouzu, Haruhiko Miyata, Masahito Ikawa, Keiichi I Nakayama

Nature communications, 13(1) 1071-1071, Feb 28, 2022
Differential effect of canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice.

Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

The Biochemical journal, 479(3) 425-444, Feb 11, 2022
Targeting leukemia-specific dependence on the de novo purine synthesis pathway.

Takuji Yamauchi, Kohta Miyawaki, Yuichiro Semba, Masatomo Takahashi, Yoshihiro Izumi, Jumpei Nogami, Fumihiko Nakao, Takeshi Sugio, Kensuke Sasaki, Luca Pinello, Daniel E Bauer, Takeshi Bamba, Koichi Akashi, Takahiro Maeda

Leukemia, 36(2) 383-393, Feb, 2022
Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories.

Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M Tokuoka, Yoshihiro Kita, Fumie Hamano, Nobuyuki Okahashi, Kazutaka Ikeda, Hiroki Nakanishi, Kosuke Saito, Masami Yokota Hirai, Masaru Yoshida, Yoshiya Oda, Fumio Matsuda, Takeshi Bamba

Metabolites, 12(2), Feb 1, 2022
Quantitative metabolomics for dynamic metabolic engineering using stable isotope labeled internal standards mixture (SILIS).

Yuki Soma, Masatomo Takahashi, Yuri Fujiwara, Noriyuki Tomiyasu, Maiko Goto, Taizo Hanai, Yoshihiro Izumi, Takeshi Bamba

Journal of bioscience and bioengineering, 133(1) 46-55, Jan, 2022
Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe.

Kosho Yamauchi, Yuta Matsuoka, Masatomo Takahashi, Yoshihiro Izumi, Hideto Naka, Yosuke Taniguchi, Kazuaki Kawai, Takeshi Bamba, Ken-Ichi Yamada

Chemical communications (Cambridge, England), 58(1) 56-59, Dec 21, 2021
Enzyme systems involved in glucosinolate metabolism in Companilactobacillus farciminis KB1089.

Hiroko Watanabe, Riku Usami, Shigenobu Kishino, Kengo Osada, Yudai Aoki, Hironobu Morisaka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Wataru Aoki, Hiroyuki Suganuma, Jun Ogawa

Scientific reports, 11(1) 23715-23715, Dec 9, 2021
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques.

Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-Ichi Yamada

Nature communications, 12(1) 6339-6339, Nov 3, 2021

Misc.

SGLT2阻害薬が肥満糖尿病マウスの骨格筋代謝に与える影響の検討

中村慎太郎, 横溝久, 大塚裕子, 和泉自泰, 高橋政友, 佐藤直市, 坂本竜一, 宮地康高, 宮澤崇, 馬場健史, 小川佳宏

糖尿病, 65(Suppl.1) S-184, Apr, 2022
超臨界流体クロマトグラフィー/質量分析を用いたメタボリックプロファイリング

高橋政友, 和泉自泰, 馬場健史

日本農薬学会誌, 41 260-266, 2016 Lead author
佃煮製造工場における嫌気性DHSリアクターを用いた余剰汚泥削減に関する実証試験

高橋政友, 三好益美, 小島俊男, 串田光祥, 多川正, 中尾均, 槙野由香利

全国環境研会誌, 38 154-159, 2013 Lead author
DHSリアクターによる食品産業排水の低コスト・省エネルギー処理技術

多川正, 西本愛, 高橋政友

食品工業, 56 47-51, 2013

Books and Other Publications

メタボロミクス実践ガイド，実践編②機器分析，Ⅱ発展的な機器分析の紹介，9 イオンクロマトグラフィー質量分析 (IC/MS) を用いた陰イオン性代謝物の分析手法

高橋政友,和泉自泰,平山明由 (Role: Joint author, 160-162)

羊土社, Mar, 2021
超臨界流体テクノロジーのフードメタボロミクスへの応用

高橋政友, 和泉自泰, 馬場健史 (Role: Joint author, 17-24)

バイオインダストリー, 2015

Professional Memberships

Apr, 2022 - Present

The Society for Biotechnology Japan
Jul, 2021 - Present

The Chem-Bio Informatics Society
Mar, 2018 - Present

The Mass Spectrometry Society of Japan
Jan, 2018 - Present

American Society for Mass Spectrometry
Apr, 2012 - Mar, 2016

Japan Society on Water Environment

Research Projects

代謝物プロファイリングによる薬物性肝障害発症メカニズムの解析

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

高橋政友

Industrial Property Rights

特開2020-186953 質量分析用標識組成物、代謝物の定量分析法、及び代謝物の動態解析法

脇村明夏里, 横山順, 寺内勉, 馬場健史, 和泉自泰, 相馬悠希, 高橋政友, 中谷航太, 秦康祐