1987年11月
High affinity interleukin 2 receptors in HTLV-1-Infected T cells can mediate signals for gene expression
Virus Genes
- ,
- ,
- ,
- ,
- 巻
- 1
- 号
- 1
- 開始ページ
- 35
- 終了ページ
- 47
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/BF00125684
- 出版者・発行元
- Kluwer Academic Publishers
The expression of transcripts of the c-myb and c-myc protooncogenes and the interleukin 2 receptor (IL-2R) gene in human T cells infected with human T-cell leukemia virus type 1 (HTLV-1) after exposure to interleukin 2 (IL-2) were examined. Infection with HTLV-1 is known to be associated with constitutive expression of IL-2R, although infected cells do not require IL-2 for growth. Northern blot analysis showed that expression of the mRNAs of the c-myb, c-myc, and IL-2R genes were markedly increased by addition of IL-2 into the cultures, indicating that IL-2R transduced signals for gene expression in these cells as in normal T cells. Studies on distinct HTLV-1-infected T cell clones that differed in numbers of high-affinity IL-2R, showed that the extents of increase in mRNA expression by IL-2 were correlated with the number of high-affinity IL-2R. This correlation was confirmed by demonstration that the levels of mRNA expression were proportional to the numbers of IL-2-bound high-affinity but not low-affinity receptors. Thus, the signals induced by IL-2 for gene expression may be through high-affinity IL-2R. © 1987 Martinus Nijhoff Publishing.
- ID情報
-
- DOI : 10.1007/BF00125684
- ISSN : 0920-8569
- ISSN : 1572-994X
- PubMed ID : 3509878
- SCOPUS ID : 0023452824