論文

査読有り 国際誌
2020年3月12日

Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety.

Scientific reports
  • Masahiro Tsuji
  • ,
  • Mariko Sawada
  • ,
  • Shinichi Watabe
  • ,
  • Hiroyuki Sano
  • ,
  • Masayo Kanai
  • ,
  • Emi Tanaka
  • ,
  • Satoshi Ohnishi
  • ,
  • Yoshiaki Sato
  • ,
  • Hisanori Sobajima
  • ,
  • Takashi Hamazaki
  • ,
  • Rintaro Mori
  • ,
  • Akira Oka
  • ,
  • Hiroyuki Ichiba
  • ,
  • Masahiro Hayakawa
  • ,
  • Satoshi Kusuda
  • ,
  • Masanori Tamura
  • ,
  • Makoto Nabetani
  • ,
  • Haruo Shintaku

10
1
開始ページ
4603
終了ページ
4603
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-61311-9

Neonatal hypoxic-ischaemic encephalopathy (HIE) is a serious condition; many survivors develop neurological impairments, including cerebral palsy and intellectual disability. Preclinical studies show that the systemic administration of umbilical cord blood cells (UCBCs) is beneficial for neonatal HIE. We conducted a single-arm clinical study to examine the feasibility and safety of intravenous infusion of autologous UCBCs for newborns with HIE. When a neonate was born with severe asphyxia, the UCB was collected, volume-reduced, and divided into three doses. The processed UCB was infused at 12-24, 36-48, and 60-72 hours after the birth. The designed enrolment was six newborns. All six newborns received UCBC therapy strictly adhering to the study protocol together with therapeutic hypothermia. The physiological parameters and peripheral blood parameters did not change much between pre- and postinfusion. There were no serious adverse events that might be related to cell therapy. At 30 days of age, the six infants survived without circulatory or respiratory support. At 18 months of age, neurofunctional development was normal without any impairment in four infants and delayed with cerebral palsy in two infants. This pilot study shows that autologous UCBC therapy is feasible and safe.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-61311-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32165664
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067794

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