論文

査読有り 国際誌
2020年4月

Mesenchymal stem/stromal cells stably transduced with an inhibitor of CC chemokine ligand 2 ameliorate bronchopulmonary dysplasia and pulmonary hypertension.

Cytotherapy
  • Toshihiko Suzuki
  • ,
  • Yoshiaki Sato
  • ,
  • Hidenori Yamamoto
  • ,
  • Taichi Kato
  • ,
  • Yuma Kitase
  • ,
  • Kazuto Ueda
  • ,
  • Haruka Mimatsu
  • ,
  • Yuichiro Sugiyama
  • ,
  • Atsuto Onoda
  • ,
  • Shigeki Saito
  • ,
  • Yoshiyuki Takahashi
  • ,
  • Takayuki Nakayama
  • ,
  • Masahiro Hayakawa

22
4
開始ページ
180
終了ページ
192
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jcyt.2020.01.009

Perinatal bronchopulmonary dysplasia (BPD) is defined as lung injury in preterm infants caused by various factors, resulting in serious respiratory dysfunction and high mortality. The administration of mesenchymal stem/stromal cells (MSCs) to treat/prevent BPD has proven to have certain therapeutic effects. However, MSCs can only weakly regulate macrophage function, which is strongly involved in the development of BPD. 7ND-MSCs are MSCs transfected with 7ND, a truncated version of CC chemokine ligand 2 (CCL2) that promotes macrophage activation, using a lentiviral vector. In the present study, we show in a BPD rat model that 7ND-MSC administration, but not MSCs alone, ameliorated the impaired alveolarization evaluated by volume density and surface area in the lung tissue, as well as pulmonary artery remodeling and pulmonary hypertension induced by BPD. In addition, 7ND-MSCs, but not MSCs alone, reduced M1 macrophages and the messenger RNA expressions of interleukin-6 and CCL2 in the lung tissue. Thus, the present study showed the treatment effect of 7ND-MSCs in a BPD rat model, which was more effective than that of MSCs alone.

リンク情報
DOI
https://doi.org/10.1016/j.jcyt.2020.01.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32139242

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