2020年9月
An autopsy case of acute myocarditis with unique lymph node findings characterized by the proliferation of reactive plasmablasts
Journal of Clinical and Experimental Hematopathology
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- 巻
- 60
- 号
- 3
- 開始ページ
- 108
- 終了ページ
- 112
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3960/jslrt.20023
- 出版者・発行元
- Japanese Society for Lymphoreticular Tissue Research
We report an autopsy case of acute myocarditis, in which the mediastinal lymph nodes exhibited unique findings. A 15-year-old Japanese boy was diagnosed with the secondary onset of acute myocarditis. No viruses were identified. Autopsy confirmed acute lymphocytic myocarditis. Lymphadenopathy was observed, especially in pulmonary hilar/mediastinal areas. Microscopically, interfollicular areas were uniformly filled with medium-sized, round cells that resembled lymphocytes. They were immunohistochemically CD3- CD5- CD19+ CD20- CD79a- Pax-5- CD138+ MUM1+ LMP1- EBNA2- cytoplasmic IgG+ IgA- and IgM-. No monotypia was observed for kappa and lambda light chains, and multiplex polymerase chain reaction analyses of immunoglobulin heavy chain variable region diversity demonstrated oligoclonal peaks, suggesting reactive change. IgG+ or VS38c+ cells frequently co-expressed Ki-67 (up to 80%). We considered these cells abundantly present in lymph nodes to be reactive plasmablasts because they were early plasma cells with proliferative activity.
- リンク情報
- ID情報
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- DOI : 10.3960/jslrt.20023
- ISSN : 1346-4280
- eISSN : 1880-9952
- PubMed ID : 32981914
- PubMed Central 記事ID : PMC7596914