論文

査読有り 国際誌
2019年5月1日

Efficacy of T-2307, a novel arylamidine, against ocular complications of disseminated candidiasis in mice.

The Journal of antimicrobial chemotherapy
  • Masahiro Abe
  • ,
  • Shigeki Nakamura
  • ,
  • Yuki Kinjo
  • ,
  • Yuka Masuyama
  • ,
  • Junichi Mitsuyama
  • ,
  • Mitsuo Kaku
  • ,
  • Yoshitsugu Miyazaki

74
5
開始ページ
1327
終了ページ
1332
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jac/dkz020

OBJECTIVES: T-2307, a novel arylamidine, shows broad-spectrum activity against pathogenic fungi, including Candida albicans. Ocular candidiasis is one of the serious complications associated with Candida bloodstream infection and is known to be refractory to conventional antifungal agents. The aim of the present study was to clarify the effectiveness of T-2307 against ocular candidiasis using a mouse model. METHODS: We evaluated ocular fungal burden in mice infected with C. albicans that received treatment with antifungal agents [T-2307, liposomal amphotericin B (LAMB) or fluconazole] for 3 consecutive days. We also assessed survival rates of mice after C. albicans infection followed by treatment for 7 consecutive days. In addition, ocular T-2307 concentrations and in vitro effectiveness against C. albicans biofilm formation were evaluated. RESULTS: The ocular fungal burdens were significantly reduced after T-2307 treatment compared with the control group (no treatment received) and were comparable with those observed following treatment with LAMB or fluconazole in both early- and late-phase treatment experiments. In addition, all of the mice treated with antifungal agents survived for 3 weeks after infection, whereas mice in the control group died within 3 days. The ocular T-2307 trough concentration was maintained above the MIC in the infected mice. An in vitro biofilm inhibition experiment showed that T-2307 suppressed C. albicans biofilm formation at the sub-MIC level, which was comparable with amphotericin B. CONCLUSIONS: Given these results in experimental disseminated candidiasis, T-2307 may be an effective treatment against the complication of ocular candidiasis.

リンク情報
DOI
https://doi.org/10.1093/jac/dkz020
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30753506

エクスポート
BibTeX RIS