論文

査読有り 国際誌
2020年2月24日

Disseminated cutaneous cryptococcosis in an immunocompetent elderly long-term pigeon fancier.

The Journal of dermatology
  • Taketoshi Futatsuya
  • ,
  • Kazushi Anzawa
  • ,
  • Takashi Mochizuki
  • ,
  • Akinobu Shoji
  • ,
  • Yasutaka Hoshino
  • ,
  • Masahiro Abe

記述言語
英語
掲載種別
DOI
10.1111/1346-8138.15280

Cutaneous cryptococcosis is classified as localized cutaneous cryptococcosis and cutaneous manifestations of disseminated cryptococcosis. The former presents as lesions, confined to isolated parts of the skin, which are neither systemically disseminated nor associated with cryptococcal fungemia or antigenemia. The latter presents as lesions through dissemination of Cryptococcus from visceral organs such as the lungs, with most cases being immunosuppressed hosts. We report the case of an immunocompetent elderly long-term pigeon fancier who presented with disseminated cutaneous cryptococcosis caused by Cryptococcus neoformans. Although the patient had been at risk of inhaling the pathogen by keeping pigeons for many years, and had been treated with topical steroids for a localized nodular lesion, the cause of development of multiple skin lesions could not be determined. The patient paradoxically showed no pulmonary or central nervous system symptoms, fungemia or glucuronoxylomannan antigenemia. Treatment with oral itraconazole 200 mg/day was not effective, but combination therapy of 5-fluorocytosine 200 mg/kg per day and fluconazole 100 mg/day resolved the disease.

リンク情報
DOI
https://doi.org/10.1111/1346-8138.15280
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32096254

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