論文

国際誌
2020年

Effect of smoking on macular function and retinal structure in retinitis pigmentosa.

Brain communications
  • Akio Oishi
  • ,
  • Kazunori Noda
  • ,
  • Johannes Birtel
  • ,
  • Masahiro Miyake
  • ,
  • Atsuyasu Sato
  • ,
  • Tomoko Hasegawa
  • ,
  • Manabu Miyata
  • ,
  • Shogo Numa
  • ,
  • Peter Charbel Issa
  • ,
  • Akitaka Tsujikawa

2
2
開始ページ
fcaa117
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/braincomms/fcaa117

Retinitis pigmentosa is an inherited neurodegenerative disease of the retina. We investigated smoking as a modifiable environmental factor for the progression of this currently untreatable disease. Clinical data, smoking history, macular function and morphology including visual acuity, visual field sensitivity, ellipsoid zone width and central retinal thickness were investigated. Association between pack × years and these parameters were evaluated using generalized estimating equation models to adjust confounding factors such as age and sex. A total of 410 patients with retinitis pigmentosa (≥20 years old; 209 female) were included, 164 had a smoking history. Patients without smoking history revealed a better visual acuity than smokers (0.39 versus 0.57, P = 0.001). The pack × years index was associated with worse visual acuity and thinner central retinal thickness after adjusting for age and sex (P = 0.0047 and 0.0099, respectively). Visual field and ellipsoid zone width showed a non-significant decline with increasing pack × years. This study indicates an association of smoking with worse macular function and structural integrity in retinitis pigmentosa patients, and hence a potential detrimental effect of smoking on the disease course.

リンク情報
DOI
https://doi.org/10.1093/braincomms/fcaa117
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33134916
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585699
ID情報
  • DOI : 10.1093/braincomms/fcaa117
  • PubMed ID : 33134916
  • PubMed Central 記事ID : PMC7585699

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