論文

国際誌
2020年12月16日

Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage.

Scientific reports
  • Yoko Okamoto
  • ,
  • Tadamichi Akagi
  • ,
  • Kenji Suda
  • ,
  • Takanori Kameda
  • ,
  • Masahiro Miyake
  • ,
  • Hanako Ohashi Ikeda
  • ,
  • Eri Nakano
  • ,
  • Akihito Uji
  • ,
  • Akitaka Tsujikawa

10
1
開始ページ
22058
終了ページ
22058
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-79151-y

Glaucoma is a multifactorial optic neuropathy, possibly involving vascular dysfunction, leading to the death of retinal ganglion cells and their axons. Disc hemorrhage (DH) is known to be closely associated with the widening of retinal nerve fiber layer defect (NFLD); however, it has not been well elucidated how DH affects retinal microvasculature. We aimed to investigate the association between DH history and longitudinal changes in superficial retinal microvasculature in NFLD. We enrolled 15 glaucoma patients with DH history (32 glaucomatous NFLD locations, with or without DH history). NFLD-angle, superficial retinal vessel density (VD), and decreased superficial retinal microvasculature (deMv)-angle were assessed using optical coherence tomography angiography for at least three times over time. The mean follow-up period and OCT/OCTA scan interval were 21.3 ± 5.4 months (range, 12-28) and 6.8 ± 0.4 months (range, 2-18), respectively. Linear mixed-effects models showed that the presence of DH history was significantly associated with an additional NFLD-angle widening of 2.19 degree/year (P = 0.030), VD decrease of 1.88%/year (P = 0.015), and deMv-angle widening of 3.78 degree/year (P < 0.001). These changes were significantly correlated with each other (P < 0.001). Thus, the widening of NFLD was closely associated with deMv, and DH was associated with a subsequent decrease in superficial retinal microvasculature in NFLD.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-79151-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33328575
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744505

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