論文

国際誌
2020年12月11日

Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study.

Journal of clinical medicine
  • Tadamichi Akagi
  • ,
  • Yoko Okamoto
  • ,
  • Takanori Kameda
  • ,
  • Kenji Suda
  • ,
  • Hideo Nakanishi
  • ,
  • Masahiro Miyake
  • ,
  • Hanako Ohashi Ikeda
  • ,
  • Tatsuya Yamada
  • ,
  • Shin Kadomoto
  • ,
  • Akihito Uji
  • ,
  • Akitaka Tsujikawa

9
12
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/jcm9124016

BACKGROUND: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. METHODS: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was introduced into the right eyes of the participants. The superficial (conjunctival) and deep (intrascleral) vasculatures of the corneal limbus using anterior-segment optical coherence tomography angiography (OCTA) and IOP were examined in both eyes at baseline and 15 min and 2 h after instillation. RESULTS: In the ripasudil group, the vessel density (VD) (median) at baseline (deep, 13.1%; superficial, 28.5%) significantly increased in both layers at 15 min (deep, 19.9%; superficial, 37.3%) and the deep layer at 2 h (deep, 14.8%; superficial, 31.6%). In the bimatoprost group, the superficial VD significantly changed over time, but the deep VD did not. The greater effect of ripasudil on IOP reduction was significantly associated with a lower baseline VD in the deep layer (at 15 min, p = 0.004; at 2 h, p = 0.018). CONCLUSIONS: Differences in the timing, depth, and extent of the effects on vasculature after instillations, could be detected using OCTA. The IOP-lowering effects of ripasudil might be associated with the deep vasculature.

リンク情報
DOI
https://doi.org/10.3390/jcm9124016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33322580
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764657

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