Masaki Takasugi

Profile Information

Affiliation: 大阪公立大学

Researcher number: 30711965
J-GLOBAL ID: 202001007780814579
researchmap Member ID: R000003771

Papers

Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma.

Ryota Yamagishi, Fumitaka Kamachi, Masaru Nakamura, Shota Yamazaki, Tomonori Kamiya, Masaki Takasugi, Yi Cheng, Yoshiki Nonaka, Yoshimi Yukawa-Muto, Le Thi Thanh Thuy, Yohsuke Harada, Tatsuya Arai, Tze Mun Loo, Shin Yoshimoto, Tatsuya Ando, Masahiro Nakajima, Hayao Taguchi, Takamasa Ishikawa, Hisaya Akiba, Sachiko Miyake, Masato Kubo, Yoichiro Iwakura, Shinji Fukuda, Wei-Yu Chen, Norifumi Kawada, Alexander Rudensky, Susumu Nakae, Eiji Hara, Naoko Ohtani

Science immunology, 7(72) eabl7209, Jun 24, 2022
Cellular senescence and the tumour microenvironment.

Masaki Takasugi, Yuya Yoshida, Naoko Ohtani

Molecular oncology, Jun 8, 2022
The role of cellular senescence and SASP in tumour microenvironment.

Masaki Takasugi, Yuya Yoshida, Eiji Hara, Naoko Ohtani

The FEBS journal, Feb 2, 2022
Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle.

Naoki Takada, Masaki Takasugi, Yoshiki Nonaka, Tomonori Kamiya, Kazuaki Takemura, Junko Satoh, Shinji Ito, Kosuke Fujimoto, Satoshi Uematsu, Kayo Yoshida, Takashi Morita, Hiroaki Nakamura, Akiyoshi Uezumi, Naoko Ohtani

Development (Cambridge, England), 149(3), Feb 1, 2022
【老化細胞を標的としたSenolyticsへの挑戦加齢性疾患を引き起こすメカニズムの理解と治療への展開】Senolytic drug開発の動向と展望

高杉征樹, 大谷直子

実験医学, 40(3) 407-412, Feb, 2022
【老化と慢性炎症】発がんにおける細胞老化と慢性炎症

高杉征樹, 大谷直子

別冊Bio Clinica: 慢性炎症と疾患, 10(2) 68-72, Oct, 2021
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.

Masaki Takasugi, Denis Firsanov, Gregory Tombline, Hanbing Ning, Julia Ablaeva, Andrei Seluanov, Vera Gorbunova

Nature communications, 11(1) 2376-2376, May 12, 2020 Peer-reviewed
Role of altered extracellular signalling in cellular senescence

Masaki Takasugi

Encyclopedia of Biomedical Gerontology 1st Edition, 178-184, Dec, 2019
The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats

Stephan Emmrich, Marco Mariotti, Masaki Takasugi, Maggie E. Straight, Alexandre Trapp, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova

bioRxiv, Nov, 2019
Erratum to: Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (Nature Communications, (2017), 8, (15287), 10.1038/ncomms15287)

Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T. Kanemaki, Chikashi Obuse, Eiji Hara

Nature Communications, 9(1), Dec 1, 2018
Emerging roles of extracellular vesicles in cellular senescence and aging.

Masaki Takasugi

Aging cell, 17(2), Apr, 2018 Peer-reviewed
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.

Masaki Takasugi, Ryo Okada, Akiko Takahashi, David Virya Chen, Sugiko Watanabe, Eiji Hara

Nature communications, 8 15729-15729, Jun 6, 2017 Peer-reviewed
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T Kanemaki, Chikashi Obuse, Eiji Hara

Nature communications, 8 15287-15287, May 16, 2017 Peer-reviewed
Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.

Seidai Sato, Yuka Kawamata, Akiko Takahashi, Yoshinori Imai, Aki Hanyu, Atsushi Okuma, Masaki Takasugi, Kimi Yamakoshi, Hiroyuki Sorimachi, Hiroaki Kanda, Yuichi Ishikawa, Saburo Sone, Yasuhiko Nishioka, Naoko Ohtani, Eiji Hara

Nature communications, 6 7035-7035, Apr 29, 2015 Peer-reviewed
Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver

Masaki Takasugi, Koji Hayakawa, Daisuke Arai, Kunio Shiota

MECHANISMS OF AGEING AND DEVELOPMENT, 134(7-8) 331-337, Jul, 2013 Peer-reviewedLead author
Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues

Masaki Takasugi

MECHANISMS OF AGEING AND DEVELOPMENT, 132(1-2) 65-71, Jan, 2011 Peer-reviewedLead authorLast authorCorresponding author
DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions.

Masaki Takasugi, Shintaro Yagi, Keiji Hirabayashi, Kunio Shiota

BMC genomics, 11 481-481, Aug 19, 2010 Peer-reviewed

Misc.

生活習慣病における細胞老化の役割

高杉征樹, 原英二

内分泌・糖尿病・代謝内科, 42(5) 380-383, May, 2016
【がん微小環境と標的治療がん幹細胞ニッチ、間質、血管・リンパ管新生の理解に基づく21世紀の新たながん治療】(第2章)がんの間質と炎症応答細胞老化シグナルとがん間質反応

高杉征樹, 大谷直子, 原英二

実験医学, 33(5) 765-769, Mar, 2015
【老化・寿命のサイエンス分子・細胞・組織・個体レベルでの制御メカニズムの解明個体老化と寿命はコントロールできるのか?】(第4章)細胞老化の重要性細胞老化の加齢性発がんにおける役割

高杉征樹, 大熊敦史, 原英二

実験医学, 31(20) 3335-3340, Dec, 2013
肥満症(第2版) 基礎・臨床研究の進歩肥満基礎研究の進歩肥満・肥満症の成因と発症機序エピジェネティック調節

高杉征樹, 大鐘潤, 塩田邦郎

日本臨床, 68(増刊2 肥満症) 307-312, Feb, 2010
エイジングおよびアンチエイジングのためのエピジェネティクス

早川晃司, 高杉征樹, 塩田邦郎

アンチ・エイジング医学, 6(1) 50-57, Feb, 2010

Books and Other Publications

よくわかる数学物理化学

高杉, 征樹

理工図書, 2009 (ISBN: 9784844607236)

Research Projects

老化・肥満で増加する血中小分子ヒアルロン酸による肝臓の炎症・線維化誘導機構の解明

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

高杉征樹
超長寿動物の老化抵抗性におけるHMM-HAの役割の解明

海外留学助成金ポストドクトラルフェローシップ, 公益財団法人上原記念生命科学財団, Apr, 2017 - Mar, 2018
エクソソームを介した細胞老化の発癌促進作用の解明

科学研究費助成事業特別研究員奨励費, 日本学術振興会, Apr, 2014 - Mar, 2017

高杉征樹
マウスにおける成熟期前からの進行性のDNAメチル化変化の原因の解析

科学研究費助成事業特別研究員奨励費, 日本学術振興会, 2011 - 2012

高杉征樹

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