論文

査読有り 国際誌
2020年5月12日

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.

Nature communications
  • Masaki Takasugi
  • ,
  • Denis Firsanov
  • ,
  • Gregory Tombline
  • ,
  • Hanbing Ning
  • ,
  • Julia Ablaeva
  • ,
  • Andrei Seluanov
  • ,
  • Vera Gorbunova

11
1
開始ページ
2376
終了ページ
2376
記述言語
英語
掲載種別
DOI
10.1038/s41467-020-16050-w

Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is unclear if exceptional polymer length of vHMM-HA is important for longevity. Here, we show that vHMM-HA (>6.1 MDa) has superior cytoprotective properties compared to the shorter HMM-HA. It protects not only NMR cells, but also mouse and human cells from stress-induced cell-cycle arrest and cell death in a polymer length-dependent manner. The cytoprotective effect is dependent on the major HA-receptor, CD44. We find that vHMM-HA suppresses CD44 protein-protein interactions, whereas HMM-HA promotes them. As a result, vHMM-HA and HMM-HA induce opposing effects on the expression of CD44-dependent genes, which are associated with the p53 pathway. Concomitantly, vHMM-HA partially attenuates p53 and protects cells from stress in a p53-dependent manner. Our results implicate vHMM-HA in anti-aging mechanisms and suggest the potential applications of vHMM-HA for enhancing cellular stress resistance.

リンク情報
DOI
https://doi.org/10.1038/s41467-020-16050-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32398747
ID情報
  • DOI : 10.1038/s41467-020-16050-w
  • PubMed ID : 32398747

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