論文

査読有り 国際誌
2018年4月

Emerging roles of extracellular vesicles in cellular senescence and aging.

Aging cell
  • Masaki Takasugi

17
2
記述言語
英語
掲載種別
DOI
10.1111/acel.12734

Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age-related accumulation of senescent cells promotes aging at least partially due to the senescence-associated secretory phenotype, whereby cells secrete high levels of inflammatory cytokines, chemokines, and matrix metalloproteinases. Emerging evidence, however, indicates that extracellular vesicles (EVs) are important mediators of the effects of senescent cells on their microenvironment. Senescent cells secrete more EphA2 and DNA via EVs, which can promote cancer cell proliferation and inflammation, respectively. Extracellular vesicles secreted from DNA-damaged cells can also affect telomere regulation. Furthermore, it has now become clear that EVs actually play important roles in many aspects of aging. This review is intended to summarize these recent progresses, with emphasis on relationships between cellular senescence and EVs.

リンク情報
DOI
https://doi.org/10.1111/acel.12734
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29392820
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847882
ID情報
  • DOI : 10.1111/acel.12734
  • PubMed ID : 29392820
  • PubMed Central 記事ID : PMC5847882

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