論文

査読有り 国際誌
2017年5月16日

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Nature communications
  • Akiko Takahashi
  • ,
  • Ryo Okada
  • ,
  • Koji Nagao
  • ,
  • Yuka Kawamata
  • ,
  • Aki Hanyu
  • ,
  • Shin Yoshimoto
  • ,
  • Masaki Takasugi
  • ,
  • Sugiko Watanabe
  • ,
  • Masato T Kanemaki
  • ,
  • Chikashi Obuse
  • ,
  • Eiji Hara

8
開始ページ
15287
終了ページ
15287
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ncomms15287

Emerging evidence is revealing that exosomes contribute to many aspects of physiology and disease through intercellular communication. However, the biological roles of exosome secretion in exosome-secreting cells have remained largely unexplored. Here we show that exosome secretion plays a crucial role in maintaining cellular homeostasis in exosome-secreting cells. The inhibition of exosome secretion results in the accumulation of nuclear DNA in the cytoplasm, thereby causing the activation of cytoplasmic DNA sensing machinery. This event provokes the innate immune response, leading to reactive oxygen species (ROS)-dependent DNA damage response and thus induce senescence-like cell-cycle arrest or apoptosis in normal human cells. These results, in conjunction with observations that exosomes contain various lengths of chromosomal DNA fragments, indicate that exosome secretion maintains cellular homeostasis by removing harmful cytoplasmic DNA from cells. Together, these findings enhance our understanding of exosome biology, and provide valuable new insights into the control of cellular homeostasis.

リンク情報
DOI
https://doi.org/10.1038/ncomms15287
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28508895
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440838
ID情報
  • DOI : 10.1038/ncomms15287
  • PubMed ID : 28508895
  • PubMed Central 記事ID : PMC5440838

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