論文

査読有り 国際誌
2010年8月19日

DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions.

BMC genomics
  • Masaki Takasugi
  • ,
  • Shintaro Yagi
  • ,
  • Keiji Hirabayashi
  • ,
  • Kunio Shiota

11
開始ページ
481
終了ページ
481
記述言語
英語
掲載種別
DOI
10.1186/1471-2164-11-481

BACKGROUND: Mitochondria are semi-autonomous, semi-self-replicating organelles harboring their own DNA (mitochondrial DNA, mtDNA), and their dysregulation is involved in the development of various diseases. While mtDNA does not generally undergo epigenetic modifications, almost all mitochondrial proteins are encoded by nuclear DNA. However, the epigenetic regulation of nuclear-encoded mitochondrial genes (nuclear mt genes) has not been comprehensively analyzed. RESULTS: We analyzed the DNA methylation status of 899 nuclear mt genes in the liver, brain, and heart tissues of mouse, and identified 636 nuclear mt genes carrying tissue-dependent and differentially methylated regions (T-DMRs). These nuclear mt genes are involved in various mitochondrial functions and they also include genes related to human diseases. T-DMRs regulate the expression of nuclear mt genes. Nuclear mt genes with tissue-specific hypomethylated T-DMRs were characterized by enrichment of the target genes of specific transcription factors such as FOXA2 in the liver, and CEBPA and STAT1 in the brain. CONCLUSIONS: A substantial proportion of nuclear mt genes contained T-DMRs, and the DNA methylation status of numerous T-DMRs should underlie tissue-dependent mitochondrial functions.

リンク情報
DOI
https://doi.org/10.1186/1471-2164-11-481
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20723256
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996977
ID情報
  • DOI : 10.1186/1471-2164-11-481
  • PubMed ID : 20723256
  • PubMed Central 記事ID : PMC2996977

エクスポート
BibTeX RIS