2013年7月
Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver
MECHANISMS OF AGEING AND DEVELOPMENT
- ,
- ,
- ,
- 巻
- 134
- 号
- 7-8
- 開始ページ
- 331
- 終了ページ
- 337
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.mad.2013.05.003
- 出版者・発行元
- ELSEVIER IRELAND LTD
In mammals, differences in liver function and aging have been observed between sexes; however, the epigenetic mechanisms underlying such differences remain largely unexplored. In this study, we investigated sex- and age-dependent DNA methylation status in the mouse liver. We analyzed 90 known sex-differentially expressed genes, and identified sex-dependent methylation in Zfp809, Hsd3b5, Treh, Cxcl11, Cyp17a1, and Nnmt genes. After 4 weeks of age, we noted the gradual establishment of sex-dependent hypomethylation in each of these genes in either males or females. The exposure of male mice to female-like growth hormone (GH) profile repressed male-predominant hypomethylation and promoted female-predominant hypomethylation. The occurrence of age-dependent hypomethylation, including at loci for which we also observed sex-dependent changes in DNA methylation, was accompanied by the downregulation of DNMT3A/B. In addition, we found that age-dependent hypomethylation was promoted through liver regeneration induced by partial hepatectomy, suggesting that DNMT activities were not enough to retain methylation levels. In conclusion, our results demonstrate that sex-dependent GH profiles influence the age-progressive hypomethylation under decreased DNMT3A/B levels in certain regions of the genome. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Web of Science ® 被引用回数 : 19
Web of Science ® の 関連論文(Related Records®)ビュー
- リンク情報
- ID情報
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- DOI : 10.1016/j.mad.2013.05.003
- ISSN : 0047-6374
- Web of Science ID : WOS:000322054700006