Masaki Takasugi

Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma.

Ryota Yamagishi, Fumitaka Kamachi, Masaru Nakamura, Shota Yamazaki, Tomonori Kamiya, Masaki Takasugi, Yi Cheng, Yoshiki Nonaka, Yoshimi Yukawa-Muto, Le Thi Thanh Thuy, Yohsuke Harada, Tatsuya Arai, Tze Mun Loo, Shin Yoshimoto, Tatsuya Ando, Masahiro Nakajima, Hayao Taguchi, Takamasa Ishikawa, Hisaya Akiba, Sachiko Miyake, Masato Kubo, Yoichiro Iwakura, Shinji Fukuda, Wei-Yu Chen, Norifumi Kawada, Alexander Rudensky, Susumu Nakae, Eiji Hara, Naoko Ohtani

Science immunology, 7(72) eabl7209, Jun 24, 2022

Cellular senescence and the tumour microenvironment.

Masaki Takasugi, Yuya Yoshida, Naoko Ohtani

Molecular oncology, Jun 8, 2022

The role of cellular senescence and SASP in tumour microenvironment.

Masaki Takasugi, Yuya Yoshida, Eiji Hara, Naoko Ohtani

The FEBS journal, Feb 2, 2022

Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle.

Naoki Takada, Masaki Takasugi, Yoshiki Nonaka, Tomonori Kamiya, Kazuaki Takemura, Junko Satoh, Shinji Ito, Kosuke Fujimoto, Satoshi Uematsu, Kayo Yoshida, Takashi Morita, Hiroaki Nakamura, Akiyoshi Uezumi, Naoko Ohtani

Development (Cambridge, England), 149(3), Feb 1, 2022

【老化細胞を標的としたSenolyticsへの挑戦加齢性疾患を引き起こすメカニズムの理解と治療への展開】Senolytic drug開発の動向と展望

高杉征樹, 大谷直子

実験医学, 40(3) 407-412, Feb, 2022

【老化と慢性炎症】発がんにおける細胞老化と慢性炎症

高杉征樹, 大谷直子

別冊Bio Clinica: 慢性炎症と疾患, 10(2) 68-72, Oct, 2021

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.

Masaki Takasugi, Denis Firsanov, Gregory Tombline, Hanbing Ning, Julia Ablaeva, Andrei Seluanov, Vera Gorbunova

Nature communications, 11(1) 2376-2376, May 12, 2020 Peer-reviewed

Role of altered extracellular signalling in cellular senescence

Masaki Takasugi

Encyclopedia of Biomedical Gerontology 1st Edition, 178-184, Dec, 2019

The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats

Stephan Emmrich, Marco Mariotti, Masaki Takasugi, Maggie E. Straight, Alexandre Trapp, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova

bioRxiv, Nov, 2019

Erratum to: Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (Nature Communications, (2017), 8, (15287), 10.1038/ncomms15287)

Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T. Kanemaki, Chikashi Obuse, Eiji Hara

Nature Communications, 9(1), Dec 1, 2018

Emerging roles of extracellular vesicles in cellular senescence and aging.

Masaki Takasugi

Aging cell, 17(2), Apr, 2018 Peer-reviewed

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.

Masaki Takasugi, Ryo Okada, Akiko Takahashi, David Virya Chen, Sugiko Watanabe, Eiji Hara

Nature communications, 8 15729-15729, Jun 6, 2017 Peer-reviewed

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T Kanemaki, Chikashi Obuse, Eiji Hara

Nature communications, 8 15287-15287, May 16, 2017 Peer-reviewed

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.

Seidai Sato, Yuka Kawamata, Akiko Takahashi, Yoshinori Imai, Aki Hanyu, Atsushi Okuma, Masaki Takasugi, Kimi Yamakoshi, Hiroyuki Sorimachi, Hiroaki Kanda, Yuichi Ishikawa, Saburo Sone, Yasuhiko Nishioka, Naoko Ohtani, Eiji Hara

Nature communications, 6 7035-7035, Apr 29, 2015 Peer-reviewed

Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver

Masaki Takasugi, Koji Hayakawa, Daisuke Arai, Kunio Shiota

MECHANISMS OF AGEING AND DEVELOPMENT, 134(7-8) 331-337, Jul, 2013 Peer-reviewedLead author

Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues

Masaki Takasugi

MECHANISMS OF AGEING AND DEVELOPMENT, 132(1-2) 65-71, Jan, 2011 Peer-reviewedLead authorLast authorCorresponding author

DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions.

Masaki Takasugi, Shintaro Yagi, Keiji Hirabayashi, Kunio Shiota

BMC genomics, 11 481-481, Aug 19, 2010 Peer-reviewed

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