masaki fukata - My portal

Profile Information

Affiliation: Professor, Neuropharmacology, Nagoya University Graduate School of Medicine

Degree: 博士（医学）(広島大学医学系研究科)

Researcher number: 00335027
ORCID ID: https://orcid.org/0000-0001-5200-9806
J-GLOBAL ID: 200901059080825148
researchmap Member ID: 1000241850

External link: https://www.med.nagoya-u.ac.jp/neuropharmacology/fukata/

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Professor, Nagoya University Graduate School of Medicine
Apr, 2023 - Mar, 2024

教授（クロスアポイント）, 生体膜研究部門, 自然科学研究機構生理学研究所
Jun, 2007 - Mar, 2023

Professor, Division of Membrane Physiology, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS)
Oct, 2005 - Mar, 2009

Metabolism and Cellular Function, PRESTO, JST
Mar, 2005 - May, 2007

Section Chief, Laboratory of Genomics and Proteomics, National Center for Geriatrics and Gerontology (NCGG), Research Institute
Apr, 2003 - Feb, 2005

Overseas Research Fellowships, Department of Physiology, University of California at San Francisco (UCSF)
Apr, 2001 - Mar, 2003

Assistant Professor, Department of Cell Pharmacology, Nagoya University Graduate School of Medicine
Apr, 2000 - Mar, 2001

JSPS (PD), Department of Cell Pharmacology, Nagoya University Graduate School of Medicine
Apr, 1998 - Mar, 2000

JSPS (DC2), Department of Biochemistry, Hiroshima University School of Medicine
Jun, 1994 - Mar, 1995

医員, 小児科学, 神戸大学医学部附属病院

Awards

2008

平成20年度文部科学大臣表彰若手科学者賞

深田正紀

Papers

103

Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity

Miyazaki Y, Otsuka T, Yamagata Y, Endo T, Sanbo M, Sano H, Kobayashi K, Inahashi H, Kornau H-C, Schmitz D …

Cell Reports, 113634-113634, Jan, 2024 Peer-reviewedLast authorCorresponding author
ADAM22 ethnic-specific variant reducing binding of membrane-associated guanylate kinases causes focal epilepsy and behavioural disorder

Nosková L*, Fukata Y*, Stránecký V, Šaligová J, Bodnárová O, Giertlová M, Fukata M#, Kmoch S#

Brain Communications, 5(6) fcad295, Oct 27, 2023 Peer-reviewedCorresponding author
Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy.

Xu Zhang, Jun-Ichi Kira, Hidenori Ogata, Tomohiro Imamura, Mikio Mitsuishi, Takayuki Fujii, Masaki Kobayashi, Kazuo Kitagawa, Yukihiro Namihira, Yusuke Ohya …

Neurology(R) neuroimmunology & neuroinflammation, 10(2), Mar, 2023 Peer-reviewed
S-palmitoylation of tyrosinase at cysteine500 regulates melanogenesis

Yoko Niki, Naoko Adachi, Masaki Fukata, Yuko Fukata, Shinichiro Oku, Chieko Makino-Okamura, Seiji Takeuchi, Kazumasa Wakamatsu, Shosuke Ito, Lieve Declercq …

Journal of Investigative Dermatology, 143(2) 317-327, Sep, 2022 Peer-reviewed
Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum.

Takafumi Kawai, Hirotaka Narita, Kohtarou Konno, Sharmin Akter, Rizki Tsari Andriani, Hirohide Iwasaki, Shoji Nishikawa, Norihiko Yokoi, Yuko Fukata, Masaki Fukata …

The Biochemical journal, 479(11) 1127-1145, May 16, 2022 Peer-reviewed
Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy

*Marieke M. van, der Knoop, *Reza Maroofian, *Yuko Fukata, Yvette van Ierland, Ehsan G. Karimiani, Anna-Elina Lehesjoki, Mikko Muona, Anders Paetau, Yuri Miyazaki …

Brain, Apr, 2022 Peer-reviewedCorresponding author
Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription

Wirth A, Labus J, Galil DA, Schill Y, Schmidt S, Bunke T, Gorinski N, Yokoi N, Fukata M, Ponimaskin E

Journal of Biological Chemistry, 2022 Peer-reviewed
14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice

Norihiko Yokoi, Yuko Fukata, Kei Okatsu, Atsushi Yamagata, Yan Liu, Makoto Sanbo, Yuri Miyazaki, Teppei Goto, Manabu Abe, Hidetoshi Kassai …

Cell Reports, 37(11) 110107-110107, Dec, 2021 Peer-reviewedLast authorCorresponding author
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro.

Chihiro Nakamoto, Yuhei Goto, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harpsøe, David E Gloriam, Kazuhiro Aoki, Tomonori Takeuchi

Molecular brain, 14(1) 173-173, Dec, 2021 Peer-reviewed
Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures

Jakob Kreye, Sukhvir K. Wright, Adriana van Casteren, Laura Stöffler, Marie-Luise Machule, S. Momsen Reincke, Marc Nikolaus, Scott van Hoof, Elisa Sanchez-Sendin, Marie A. Homeyer …

J Exp Med, 218(11) e20210012, Sep, 2021 Peer-reviewed
Trans-synaptic LGI1–ADAM22–MAGUK in AMPA and NMDA receptor regulation

Yuko Fukata, Yoko Hirano, Yuri Miyazaki, Norihiko Yokoi, Masaki Fukata

Neuropharmacology, 194 108628-108628, Aug, 2021 Peer-reviewedInvitedLast authorCorresponding author
MAGUKs are essential, but redundant, in long-term potentiation

Xiumin Chen, Yuko Fukata, Masaki Fukata, Roger A. Nicoll

Proceedings of the National Academy of Sciences, 118(28) e2107585118-e2107585118, Jul, 2021 Peer-reviewed
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.

Tomoyuki Yoshida, Atsushi Yamagata, Ayako Imai, Juhyon Kim, Hironori Izumi, Shogo Nakashima, Tomoko Shiroshima, Asami Maeda, Shiho Iwasawa-Okamoto, Kenji Azechi …

Nature communications, 12(1) 1848-1848, Mar, 2021 Peer-reviewed
LGI1–ADAM22–MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention

Yuko Fukata, Xiumin Chen, Satomi Chiken, Yoko Hirano, Atsushi Yamagata, Hiroki Inahashi, Makoto Sanbo, Hiromi Sano, Teppei Goto, Masumi Hirabayashi …

Proceedings of the National Academy of Sciences, 118(3) e2022580118-e2022580118, Jan 19, 2021 Peer-reviewedLast authorCorresponding author
Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex

Hidenori Watanabe, Hiromi Sano, Satomi Chiken, Kenta Kobayashi, Yuko Fukata, Masaki Fukata, Hajime Mushiake, Atsushi Nambu

Nature Communications, 11(1), Dec, 2020 Peer-reviewed
The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts

Yukako Oda, Taichi Sugawara, Yuko Fukata, Yasushi Izumi, Tetsuhisa Otani, Tomohito Higashi, Masaki Fukata, Mikio Furuse

Journal of Biological Chemistry, Feb 20, 2020 Peer-reviewed
Human CSF monoclonal LGI1 autoantibodies increase neuronal excitability

Kornau HC, Kreye J, Stumpf A, Fukata Y, Parthier D, Sammons RP, Imbrosci B, Kurpjuweit S, Kowski AB, Fukata M …

Ann Neurol, Jan, 2020 Peer-reviewed
Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.

Ryota Sada, Hirokazu Kimura, Yuko Fukata, Masaki Fukata, Hideki Yamamoto, Akira Kikuchi

Science signaling, 12(608) eaat9519, Nov 19, 2019 Peer-reviewed
ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5.

Cao Y, Qiu T, Kathayat R, Azizi SA, Fukata Y, Fukata M, Rice P, Dickinson BC

15 1232-1240, Nov, 2019 Peer-reviewed
Targeting CCR5 trafficking to inhibit HIV-1 infection.

Boncompain G, Herit F, Tessier S, Lescure A, Del Nery E, Gestraud P, Staropoli I, Fukata Y, Fukata M, Brelot A …

Science Advances, 5 eaax0821, Oct, 2019 Peer-reviewed

Misc.

てんかん発症を抑制するためのLGI1–ADAM22タンパク質複合体の量的制御機構

横井紀彦, 深田優子, 深田正紀

生化学, 95(3) 384-388, Jun, 2023 Peer-reviewedInvitedLast author
Acyl-PEGyl exchange gel-shift (APEGS) assay for palmitoylation quantification

Masaki Fukata, Norihiko Yokoi, Yuko Fukata

Electrophoresis Letters, 65(2) 41-45, 2021 Peer-reviewedInvitedLead authorLast authorCorresponding author
てんかん関連リガンド・受容体 LGI1・ADAM22

平野瑶子, 宮﨑裕理, 深田正紀, 深田優子

膜タンパク質工学ハンドブック, 357-365, Apr, 2020 Peer-reviewedInvited
zDHHC パルミトイル化酵素と ABHD17 脱パルミトイル化酵素

深田正紀, 横井紀彦, 平田哲也, 深田優子

膜タンパク質工学ハンドブック, 316-323, Apr, 2020 Peer-reviewedInvitedLead authorCorresponding author
パルミトイル化修飾酵素を軸とした神経機能研究

平田哲也, 深田優子, 深田正紀

生化学, 90(2) 125-137, 2018 Peer-reviewedInvited
記憶・学習に関わるメンブレントラフィック

深田優子, 横井紀彦, 宮﨑裕理, 深田正紀

メンブレントラフィック, 化学同仁, (19) 157-175, 2016 Peer-reviewedInvited
ケミカルシャペロンを用いたタンパク質構造異常の修復はてんかんモデルマウスの上昇した痙攣感受性を軽減する

横井紀彦, 深田優子, 深田正紀

細胞工学, 85 512-513, 2015 Peer-reviewedInvited
シナプス伝達修飾分子LGI1の機能異常による“てんかん”発症

横井紀彦, 深田優子, 深田正紀

メディカルバイオ, 7(3) 40-47, May, 2010 Peer-reviewedInvitedCorresponding author
LGI1が仲介するタンパク質複合体の破綻はシナプス伝達異常とてんかんを引き起こす

岩永剛, 深田正紀, 深田優子

細胞工学, 29(6), 2010 Peer-reviewedInvited
The Molecular Mechanisms for AMPA Receptor Trafficking

FUKATA Masaki, FUKATA Yuko

28(3) 131-134, Jun, 2008 Peer-reviewedInvited
PSD-95パルミトイル化脂質修飾酵素によるAMPA受容体動態制御メカニズム

則竹淳, 深田優子, 深田正紀

蛋白質核酸酵素, 53(4) 430-435, Apr, 2008 Peer-reviewedInvitedCorresponding author
Protein palmitoylating enzymes

TSUTSUMI Ryouhei, FUKATA Yoko, FUKATA Masaki

80(12) 1119-1123, 2008 Peer-reviewedInvited
Epilepsy-related LGI1 functions as a synaptic modulator through ADAM22

Protein, nucleic acid and enzyme, 52(5) 449-455, May, 2007 Peer-reviewedInvitedLast authorCorresponding author
パルミトイル化脂質修飾をつかさどる新規DHHC蛋白質ファミリー

深田優子, 深田正紀

蛋白質核酸酵素, 50(13) 1666-1673, Nov, 2005 Peer-reviewedInvitedLast authorCorresponding author
遺伝子導入と遺伝子ノックダウン : 新しい時代を迎える生細胞観察(I.遺伝子操作法と組織化学)

渡辺崇, 深田正紀, 貝淵弘三

組織細胞化学, 2003 9-15, Jul 10, 2003
Mechanisms of Cell Adhesion and Cell Polarization in Rho Family GTPases

51(1) 151-160, Jul, 2003
低分子量GTP結合タンパク質Rac1,Cdc42と標的タンパク質IQGAP1による微小管捕捉機構

深田正紀, 渡辺崇, 則竹淳, 中川誠人, 貝淵弘三

細胞工学, 21(9) 1064-1065, Aug, 2002 InvitedLead author
低分子量GTP結合タンパク質Rac1,Cdc42と標的タンパク質IQGAP1による細胞間接着の制御

深田正紀, 中川誠人, 山鹿真幸, 貝淵弘三

細胞工学, 20(4) 548-551, Apr, 2001 Peer-reviewedInvitedLead author
Rhoファミリーによる細胞骨格、細胞接着の再構築

深田正紀, 黒田真也, 中川誠人, 貝淵弘三

細胞工学, 17(12) 1844-1855, Dec, 1998 Peer-reviewedInvitedLead author
Cdc42、Rac1と標的タンパク質による細胞接着シグナル

深田正紀, 黒田真也, 小林憲太, 貝淵弘三

細胞工学, 15(12) 1724-1731, Dec, 1996 Peer-reviewedInvitedLead author

Professional Memberships

Research Projects

神経シナプスの成熟機構とその破綻による“てんかん"の分子病態

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2020 - Mar, 2023

深田正紀
S-アシル化修飾ゾーンによるシナプス機能制御

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2020 - Mar, 2022

深田正紀
Clarify the pathological mechanism for autoimmune encephalitis using recombinant autoantibodies

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2022

Fukata Masaki
数理解析を目指したパルミトイル化シグナル伝達研究

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2019 - Mar, 2021

深田正紀
S-アシル化修飾ゾーンとシナプス機能

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2018 - Mar, 2020

深田正紀
Molecular mechanism for synapse-nanocolumn formation and synapse disorders

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Fukata Masaki
LGI1を中心とするシナプス蛋白質ネットワークの老化と認知症の分子病態

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2017 - Mar, 2019

深田正紀
神経シナプス膜のナノドメイン構築と脂質環境

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2016 - Mar, 2018

深田正紀
Optogenetic manipulation of protein palmitoylation for synapse organization

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Masaki Fukata, FUKATA Yuko, YOKOI Norihiko, HIRATA Tetsuya, INAHASHI Hiroki, KANADOME Takashi, SUZUKI Yumi, WATANABE Mie
記憶と脳の安定性を保持するLGI1リガンドの老化と認知症における役割

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

深田正紀
Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variant

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

KUBO Yoshihiro, YAMAMOTO Izumi, WATANABE Masahiro, Chen I-Shan, Yamamoto Tomomi, TATEYAMA Michihiro, TAKAO Keizo, MIYAKAWA Tsuyoshi, HATTORI Satoko, FUKATA Masaki, FUKATA Yuko, YOKOI Norihiko, SAKIMURA Kenji, SYUU Rei, NATSUME Rie
Identification of depalmitoylating enzymes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

FUKATA Masaki, FUKATA Yuko, YOKOI Norihiko, SEKIYA Atsushi, MURAKAMI Tatsuro, TAKAHASHI Naoki, SUZUKI Yumi, WATANABE Mie
analysis of newly target auto antigens in autoimmune encephalitis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Watanabe Osamu, KISHIDA Shosei, Takashima Hiroshi, Fukata Masaki
Comprehensive Brain Science Network

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

Kimura Minoru, Tanji Jun, Takada Masahiko, Nakamura Katsuki, Ohtsuka Toshihisa, Aoki Shigeki, Takao Hidemasa, Shimoji Keigo, Goto Masami, Yoshiura Takashi, Nakata Yasuhiro, Abe Osamu, Masumoto Tomohiko, Tokumaru Aya, Matsumura Akira, Kirino Eiji, Terada Hitoshi, Sato Noriko, Kasai Kiyoto, Hashimoto Ryota, Niwa Shin-ichi, Kato Tadafumi, Suzuki Michio, Shuji Iritani, Nemoto Kiyotaka, Tomita Hiroaki, Murayama Shigeo, Akatsu Hiroyasu, Takao Masaki, Saito Yuko, Bito Haruhiko, Yoshimura Yumiko, Matsuzaki Masanori, Furuta Toshiaki, Okado Haruo, Saito Izumu, Kaibuchi Kozo, Hasegawa Masato, Aiba Atsu, Shiina Nobuyuki, Igarashi Michihiro, Tomoki Nishioka, Watanabe Masahiko, Koike Masato, Sakagami Hiroyuki, Shigemoto Ryuichi, Fukazawa Yugo, Sakimura Kenji, Mori Hisashi, Mishina Masayoshi, Kobayashi Kazuto, Yanagawa Yuchio, Uemura Tadashi, Ishihara Takeshi, Nose Akinao, Iino Yuichi, Miyakawa Tsuyoshi, Takao Keizo, Mushiake Hajime, Katayama Norihiro, Tanaka Tetsu, Inoue Kazuhide, Okabe Shigeo, Kano Masanobu, Fujiyama Fumino, Isa Tadashi, Kageyama Ryoichiro, Fujita Ichiro, Yoshida Akira, Nishikawa Toru, Nukina Nobuyuki, Fukai Tomoki, Iwatsubo Takeshi, Yamamori Tetsuo, Okazawa Hitoshi, Tanaka Keiji, Kakigi Ryusuke, Tsuda Ichiro, Kitazawa Shigeru, Doya Kenji, Takahashi Ryosuke, Ikenaka Kazuhiro, Sobue Gen, Hasegawa Toshikazu, Ota Jun, Saitoe Minoru, Kadomatsu Kenji, Kida Satoshi, Manabe Toshiya, Tomita Taisuke, Iwata Atsushi, Murakami Ikuya, Tsutsui Ken-ichiro, Hanakawa Takashi, Hirai Hirokazu, Mima Tatsuya, Isomura Yoshikazu, Samejima Kazuyuki, Hoshi Eiji, Miyata Mariko, Yuzaki Michisuke, Tanaka Masaki, Fukata Masaki, Suzuki Kyoko, Kuba Hiroshi, Masu Masayuki, Kinoshita Makoto, Sugihara Izumi, Shirane Michiko, Yamamoto Nobuhiko, Nishijo Hisao, Nambu Atsushi, Takumi Toru, Yamashita Toshihide, Sakurai Takeshi, Tamamaki Nobuaki, Hata Yoshio, Harada Akihiro, Ozaki Norio, Sakai Katsuyuki, Kubo Yoshihiro, Nakazawa Takanobu, Tanaka Kenji, Takei Nobuyuki, Hitoshi Seiji, Takahiroa. Kato, Kato Fusao, Shirao Tomoaki, Taira Masato, Okano Hideyuki, Sekino Yuko, Okamoto Yasumasa, KOMATSU Hidehiko, Miyata Takaki, Takahashi Yoshiko, Nishida Shinya, Tominaga Makoto
新規AMPA受容体制御因子群によるシナプス機能制御の解明

科学研究費助成事業, 若手研究(S), 日本学術振興会, 2008 - 2012

深田正紀
パルミトイルサイクルによるG蛋白質の動態制御機構

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

深田正紀
PSD-95パルミトイル化酵素によるシナプス機能制御

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

深田正紀
新規パルミトイル化酵素群の活性制御機構の解明

科学研究費助成事業, 若手研究(A), 日本学術振興会, 2006 - 2008

深田正紀
パルミトイルサイクルによるG蛋白質の動態制御機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

深田正紀, 深田優子
PSD-95パルミトイル化酵素によるAMPA受容体動態制御機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

深田正紀, 深田優子

Education

Apr, 1996 - Mar, 2000

生理系専攻, 医学系研究科, 広島大学大学院
Apr, 1988 - Mar, 1994

Faculty of Medicine, School of Medicine, Kobe University