2018年10月
Amrubicin monotherapy for elderly patients with relapsed extensive-disease small-cell lung cancer: A retrospective study
Thoracic Cancer
- 巻
- 9
- 号
- 10
- 開始ページ
- 1279
- 終了ページ
- 1284
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/1759-7714.12833
- 出版者・発行元
- Wiley
BACKGROUND: Previous studies have shown amrubicin (AMR) to be an effective second-line treatment option for small-cell lung cancer (SCLC). However, the efficacy of AMR in elderly patients with relapsed SCLC has not been sufficiently evaluated. METHODS: The medical records of elderly patients with relapsed SCLC who received AMR as second-line chemotherapy were retrospectively reviewed, and their treatment outcomes were evaluated. RESULTS: Thirty-one patients with a median age of 72 years (22 patients with sensitive relapse and 9 with refractory relapse) were analyzed. The median number of treatment cycles was four (range: 1-10), and the response rate was 29%. The median progression-free survival (PFS) and overall survival (OS) were 5.4 and 11.6 months, respectively. The OS of 22 patients who received third-line chemotherapy was 15.5 months. The PFS (6.2 vs. 3.2 months; P = 0.002) and OS (14.8 vs. 5.7 months; P = 0.004) were significantly longer in patients with sensitive relapse than those with refractory relapse. The frequency of grade 3 or higher neutropenia was high (n = 18, 58%), while febrile neutropenia was only observed in five patients (16%). Non-hematological toxic effects were relatively mild, and pneumonitis and treatment-related deaths were not observed. CONCLUSION: AMR may be a feasible and effective regimen for elderly patients with relapsed SCLC.
- リンク情報
- ID情報
-
- DOI : 10.1111/1759-7714.12833
- ISSN : 1759-7706
- PubMed ID : 30126051
- PubMed Central 記事ID : PMC6166081