2017年1月
A complex dominance hierarchy is controlled by polymorphism of small RNAs and their targets
NATURE PLANTS
- 巻
- 3
- 号
- 1
- 開始ページ
- 16206
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nplants.2016.206
- 出版者・発行元
- NATURE PUBLISHING GROUP
In diploid organisms, phenotypic traits are often biased by effects known as Mendelian dominant-recessive interactions between inherited alleles. Phenotypic expression of SP11 alleles, which encodes the male determinants of self-incompatibility in Brassica rapa, is governed by a complex dominance hierarchy(1-3). Here, we show that a single polymorphic 24 nucleotide small RNA, named SP11 methylation inducer 2 (Smi2), controls the linear dominance hierarchy of the four SP11 alleles (S-44 > S-60 > S-40 > S-29). In all dominant-recessive interactions, small RNA variants derived from the linked region of dominant SP11 alleles exhibited high sequence similarity to the promoter regions of recessive SP11 alleles and acted in trans to epigenetically silence their expression. Together with our previous study(4), we propose a new model: sequence similarity between polymorphic small RNAs and their target regulates mono-allelic gene expression, which explains the entire five-phased linear dominance hierarchy of the SP11 phenotypic expression in Brassica.
- リンク情報
- ID情報
-
- DOI : 10.1038/nplants.2016.206
- ISSN : 2055-026X
- eISSN : 2055-0278
- Web of Science ID : WOS:000395899200008