論文

査読有り 国際誌
2020年5月1日

Balloon pulmonary angioplasty improves right atrial reservoir and conduit functions in chronic thromboembolic pulmonary hypertension

European Heart Journal - Cardiovascular Imaging
  • Yuzo Yamasaki
  • Kohtaro Abe
  • Takeshi Kamitani
  • Kazuya Hosokawa
  • Masateru Kawakubo
  • Koji Sagiyama
  • Tomoyuki Hida
  • Yuko Matsuura
  • Yuriko Murayama
  • Ryohei Funatsu
  • Hiroyuki Tsutsui
  • Hidetake Yabuuchi
  • 全て表示

21
8
開始ページ
855
終了ページ
862
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/ehjci/jeaa064
出版者・発行元
Oxford University Press (OUP)

<title>Abstract</title>
<sec>
<title>Aims</title>
Right atrial (RA) function largely contributes to the maintenance of right ventricular (RV) function. This study investigated the effect of balloon pulmonary angioplasty (BPA) on RA functions in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) using cardiac magnetic resonance imaging (CMRI).


</sec>
<sec>
<title>Methods and results</title>
CMRI and RV catheterization were performed before BPA sessions and at the follow-up periods in 29 CTEPH patients. Reservoir [RA longitudinal strain (RA-LS)], passive conduit [RA early LS rate (LSR)], and active (RA late LSR) phases were assessed by using cine CMRI and a feature-tracking algorithm. The relationships between the changes in RA functions and in brain natriuretic peptide (BNP) were evaluated in both the dilated and non-dilated RA groups. RA-LS (32.4% vs. 42.7%), RA LSR (6.3% vs. 8.3%), and RA early LSR (−2.3% vs. −4.3%) were improved after BPA, whereas no significant change was seen in RA late LSR. The changes in RA peak LS and in RA early LSR were significantly correlated with the changes in BNP (ΔRA-LS: r = −0.63, ΔRA-early LSR: r = 0.65) and pulmonary vascular resistance (PVR) (ΔRA-LS: r = −0.69, ΔRA-early LSR: r = 0.66) in the nondilated RA group.


</sec>
<sec>
<title>Conclusion</title>
The RA reservoir and passive conduit functions were impaired in inoperable CTEPH, whereas RA active function was preserved. BPA markedly reversed these impaired functions. The improvements in RA reservoir and conduit functions were significantly correlated with the changes in BNP levels and PVR in CTEPH patients with normal RA sizes.


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リンク情報
DOI
https://doi.org/10.1093/ehjci/jeaa064
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32359071
URL
http://academic.oup.com/ehjcimaging/advance-article-pdf/doi/10.1093/ehjci/jeaa064/33152622/jeaa064.pdf
ID情報
  • DOI : 10.1093/ehjci/jeaa064
  • ISSN : 2047-2404
  • eISSN : 2047-2412
  • PubMed ID : 32359071

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