masato hasegawa

J-GLOBAL         Last updated: Jun 14, 2019 at 19:36
 
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masato hasegawa

Published Papers

 
Tau and TDP-43 accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts or hemorrhage.
Hatsuta H, Takao M, Nogami A, Uchino A, Sumikura H, Takata T, Morimoto S, Kanemaru K, Adachi T, Arai T, Hasegawa M, Murayama S
Acta Neuropathol Commun   7(1) 49   Mar 2019   [Refereed]
Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models.
Coudert L, Nonaka T, Bernard E, Hasegawa M, Schaeffer L, Leblanc P
Cell Mol Life Sci      2019   [Refereed]
Tau isoform expression and phosphorylation in marmoset brains.
Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI.
J Biol Chem      2019   [Refereed]
The effect of truncation on prion-like properties of α-synuclein.
Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, and Hasegawa M.
J Biol Chem   293 13910-13920   Sep 2018   [Refereed]
N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical and hippocampal neurons and microglia is dependent on calcium sensors and is blocked by α-synuclein, Tau and phospho-Tau in non-transgenic and transgenic APPSw, Ind mice.
Franco R, Andrésn DA, Canela EI, Lillo J, Tarutani A, Hasegawa M, Del Rio JA, Kreutz MR, Saura C, Navarro D.
Front Mol Neurosci.   11 273   Aug 2018   [Refereed]
C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation of phosphorylated TDP-43.
Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado, H., Hasegawa, M
Hum Mol Genet,   27(15) 2658-2670   May 2018   [Refereed]
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.
Tarutani, A, Arai T Murayama, S., Hisanaga, S.I., Hasegawa, M.
Acta Neuropathol Commun   6 29   Apr 2018   [Refereed]
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.
Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar J, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hasegawa M, José Antonio del Río.
Mol Neurobiol   55 1861   Mar 2018   [Refereed]
Molecular mechanisms of the co-deposition of multiple pathological proteins in neurodegenerative diseases.
Nonaka T, Masuda-Suzukake M, Hasegawa M
Neuropathology   38(1) 64-71   Feb 2018   [Refereed][Invited]
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga SI.
J Biol Chem   293 1781-1793   Feb 2018   [Refereed]
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.
Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R.
Stem Cell Rep   10 356-365   Feb 2018   [Refereed]
Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.
Kametani F and Hasegawa M.
Front Neurosci   12 25   Jan 2018   [Refereed]
Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome.
Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H.
Sci Rep   8 819   Jan 2018   [Refereed]
Shimozawa A, Ono M, Takahara D, Tarutani A, Imura S, Masuda-Suzukake M, Higuchi M, Yanai K, Hisanaga SI, Hasegawa M.
Acta Neuropathol Commun.   5((1)) 12.   Feb 2017   [Refereed]
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
Hum Mol Genet   26 969-988   Jan 2017   [Refereed]
α-Synuclein: Experimental pathology.
Hasegawa M, Nonaka T, Masuda-Suzukake M.
Cold Spring Harb Perspect Med   6 305-318   2017   [Refereed]
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.
Hasegawa M, Nonaka T, Masuda-Suzukake M.
Pharmacol Ther   172 22-33   2017   [Refereed]
Following the fate of endocytosed fibrils.
Hasegawa M and Suzuki G.
J Biol Chem   292(32) 13498-13499   2017   [Refereed]
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
Mano T, Nagata K, Nonaka, T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A.
Proc Natl Acad Sci USA   114 E9645-E9654.   2017   [Refereed]
Wild-type monomeric α-synuclein can impair vesicle endocytosis and synaptic fidelity via tubulin polymerization at the calyx of Held.
Eguchi K, Taoufiq Z, Thorn-Seshold O, Trauner D, Hasegawa M, Takahashi T.
J Neurosci   37 6043-6052   2017   [Refereed]
Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.
Hosokawa M, Kondo H, Serrano GE, Beach TG, Robinson AC, Mann DM, Akiyama H, Hasegawa M, Arai T.
Sci Rep   7 1513   2017   [Refereed]
Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
J Biol Chem   291 18675-88   Sep 2016   [Refereed]
Oikawa T, Nonaka T, Terada M, Tamaoka A, Hisanaga S, Hasegawa M.
J Biol Chem   291 15046-56   Jul 2016   [Refereed]
Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
Hum Mol Genet   25 1420-33   Apr 2016   [Refereed]
Shimonaka S, Nonaka T, Suzuki G, Hisanaga SI, Hasegawa M.
J Biol Chem   291 8896-907   Apr 2016   [Refereed]
Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
J Biol Chem   291 5473-83   Mar 2016   [Refereed]
Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, Yoshida M, & Hasegawa M.
Sci Rep   6 23281   Mar 2016   [Refereed]
Taniguchi‑Watanabe S, Arai T, Kametani F, Nonaka T, Masuda‑Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M. Akiyama H, Robinson A, Mann D, Iwatsubo T, Hasegawa M.
Acta Neuropathol   131 267-80   2016   [Refereed]
Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation.
Hasegawa M
Biomolecules   6    2016   [Refereed]
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.
Hasegawa M, Nonaka T, Masuda-Suzukake M.
Pharmacol Ther   30236-4   2016   [Refereed]
Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga S, Hasegawa M.
Acta Neuropathol   29 895-907   2015   [Refereed]
Matsumoto SE, Motoi Y, Ishiguro K, Tabira T, Kametani F, Hasegawa M, Hattori N.
Hum Mol Genet   24 6403-16   2015   [Refereed]
Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H.
J Neuropathol Exp Neurol   74 158-65   2015   [Refereed]
Baborie A, Griffiths TD, Jaros E, Perry R, McKeith IG, Burn DJ, Masuda-Suzukake M, Hasegawa M, Rollinson S, Pickering-Brown S, Robinson AC, Davidson YS, Mann DM.
Neuropathol Appl Neurobiol   41 601-12   2015   [Refereed]
Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A, Akiyama H, Hasegawa M.
Acta Neuropathol Commun   2 88   2014   [Refereed]
Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M.
Hum Mol Genet   23 4345-56   2014   [Refereed]
Hasegawa M, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S.
Acta Neuropathol   127 303-305   2014   [Refereed]
Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
Cell Rep   4 124-134   2013   [Refereed]
Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M
Acta Neuropathol Comm   1 54   2013   [Refereed]
Tsuji H, Nonaka T, Yamashita M, Suzukake M, Kametani F, Akiyama H, Mann DM, Tamaoka A and Hasegawa M
Biochem Biophys Res Commun   417 116-121   2012   [Refereed]
Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuta H, Takao M, Saito Y, Murayama M, Akiyama H, Hasegawa M, Mann DMA, Tamaoka A.
Brain   135 3380-3391   2012   [Refereed]
Hasegawa M, Nonaka T, Tsuji H, Tamaoka A, Yamashita M, Kametani F, Yoshida M, Arai T, Akiyama H.
J Mol Neurosci   45 480-485   2011   [Refereed][Invited]
Kobayashi Z, Tsuchiya K, Arai T, Aoki M, Hasegawa M, Ishizu H, Akiyama H, Mizusawa H
Journal of the neurological sciences   293(1-2) 6-11   Apr 2010   [Refereed]
Yamaguchi Y, Masuda M, Sasakawa H, Nonaka T, Hanashima S, Hisanaga S, Kato K, Hasegawa M
Journal of molecular biology   395(3) 445-456   Jan 2010   [Refereed]
Arai T, Hasegawa M, Nonoka T, Kametani F, Yamashita M, Hosokawa M, Niizato K, Tsuchiya K, Kobayashi Z, Ikeda K, Yoshida M, Onaya M, Fujishiro H, Akiyama H
Neuropathology : official journal of the Japanese Society of Neuropathology      Jan 2010   [Refereed]
Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M.
Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M.   285 34885-98   2010   [Refereed]
Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H
Internal medicine (Tokyo, Japan)   49(4) 331-334   2010   [Refereed]
Hasegawa M, Nonaka T, Yamashita M, Kametani F, Arai T, Yoshida M, Hashizume Y, Tsuchiya K, Akiyama H
Rinsho shinkeigaku = Clinical neurology   49(11) 783-785   Nov 2009   [Refereed]
[The molecular mechanisms of intracellular TDP-43 aggregates]
Nonaka T, Arai T, Hasegawa M
Brain and nerve = Shinkei kenkyu no shinpo   61 1292-1300   Nov 2009   [Refereed]
Foulds PG, Davidson Y, Mishra M, Hobson DJ, Humphreys KM, Taylor M, Johnson N, Weintraub S, Akiyama H, Arai T, Hasegawa M, Bigio EH, Benson FE, Allsop D, Mann DM
Acta neuropathologica   118 647-658   Nov 2009   [Refereed]

Books etc

 
TDP-43 prions.
Nonaka T and Hasegawa M. (Part:Contributor, Cold Spring Harb Perspect Med, Chapter 41)
Cold Spring Harbor Laboratory Press   Jan 2017   
α-Synuclein: Experimental pathology.
Hasegawa M, Nonaka T, Masuda-Suzukake M. (Part:Contributor, Cold Spring Harb Perspect Med 6(9).)
Cold Spring Harbor Laboratory Press   2016   
Molecular Biology of Dementia with Lewy Bodies,
Hasegawa M (Part:Contributor, Dementia with Lewy Bodies, Chapter 4: P41-58,)
Springer, Edited by Kenji Kosaka.   2016   

Conference Activities & Talks

 
Prion-like propagation of pathological tau in neurodegenerative diseases [Invited]
Hasegawa M
Japan-UK Neuroscience Symposium   10 Feb 2019   
Prion-like propagation of pathological tau in neurodegenerative diseases. [Invited]
Hasegawa M
ICN2018   24 Sep 2018   
α-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy [Invited]
Hasegawa M
MDS/Education/Conferences & Courses   3 Aug 2018   
Tau aggregation mechanisms and therapeutic strategies for AD [Invited]
Hasegawa M
59th Annual Meeting of The Japanese Society of Neurology   25 May 2018   
Transmission of αSynuclein [Invited]
Hasegawa M
16th International Symposium on Amyloidosis (ISA2018)   28 Mar 2018