2020年7月17日
Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
eneuro
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- 巻
- 7
- 号
- 4
- 開始ページ
- ENEURO.0072
- 終了ページ
- 20.2020
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1523/ENEURO.0072-20.2020
- 出版者・発行元
- Society for Neuroscience
© 2020 Parajuli et al. The aging process is accompanied by various neurophysiological changes, and the severity of neurodegenera-tive disorders such as Parkinson’s disease (PD) increases with aging. However, the precise neuroanatomical changes that accompany the aging process in both normal and pathologic conditions remain unknown. This is in part because there is a lack of high-resolution imaging tool that has the capacity to image a desired volume of neurons in a high-throughput and automated manner. In the present study, focused ion beam/scanning electron microscopy (FIB/SEM) was used to image striatal neuropil in both wild-type (WT) mice and an A53T bacterial artificial chromosome (BAC) human α-synuclein (A53T-BAC-SNCA) transgenic (Tg) mouse model of PD, at 1, 3, 6, and 22 months of age. We demonstrated that spine density gradually decreases, and average spine head volume gradually increases with age in WT mice, suggesting a homeostatic balance between spine head volume and spine density. However, this inverse relationship between spine head volume and spine density was not observed in A53T-BAC-SNCA Tg mice. Taken together, our data suggest that PD is accompanied by an abnormality in the mechanisms that control synapse growth and maturity.
- リンク情報
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- DOI
- https://doi.org/10.1523/ENEURO.0072-20.2020
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32817196
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090076399&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85090076399&origin=inward
- ID情報
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- DOI : 10.1523/ENEURO.0072-20.2020
- eISSN : 2373-2822
- ORCIDのPut Code : 78961985
- PubMed ID : 32817196
- SCOPUS ID : 85090076399