論文

査読有り 最終著者 責任著者 本文へのリンクあり
2020年7月17日

Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

eneuro
  • Laxmi Kumar Parajuli
  • ,
  • Ken Wako
  • ,
  • Suiki Maruo
  • ,
  • Soichiro Kakuta
  • ,
  • Tomoyuki Taguchi
  • ,
  • Masashi Ikuno
  • ,
  • Hodaka Yamakado
  • ,
  • Ryosuke Takahashi
  • ,
  • Masato Koike

7
4
開始ページ
ENEURO.0072
終了ページ
20.2020
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/ENEURO.0072-20.2020
出版者・発行元
Society for Neuroscience

© 2020 Parajuli et al. The aging process is accompanied by various neurophysiological changes, and the severity of neurodegenera-tive disorders such as Parkinson’s disease (PD) increases with aging. However, the precise neuroanatomical changes that accompany the aging process in both normal and pathologic conditions remain unknown. This is in part because there is a lack of high-resolution imaging tool that has the capacity to image a desired volume of neurons in a high-throughput and automated manner. In the present study, focused ion beam/scanning electron microscopy (FIB/SEM) was used to image striatal neuropil in both wild-type (WT) mice and an A53T bacterial artificial chromosome (BAC) human α-synuclein (A53T-BAC-SNCA) transgenic (Tg) mouse model of PD, at 1, 3, 6, and 22 months of age. We demonstrated that spine density gradually decreases, and average spine head volume gradually increases with age in WT mice, suggesting a homeostatic balance between spine head volume and spine density. However, this inverse relationship between spine head volume and spine density was not observed in A53T-BAC-SNCA Tg mice. Taken together, our data suggest that PD is accompanied by an abnormality in the mechanisms that control synapse growth and maturity.

リンク情報
DOI
https://doi.org/10.1523/ENEURO.0072-20.2020
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32817196
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090076399&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85090076399&origin=inward
ID情報
  • DOI : 10.1523/ENEURO.0072-20.2020
  • eISSN : 2373-2822
  • ORCIDのPut Code : 78961985
  • PubMed ID : 32817196
  • SCOPUS ID : 85090076399

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