2019年9月
Development of a Model of Porcine Epidemic Diarrhea in Microminipigs.
Veterinary pathology
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- 巻
- 56
- 号
- 5
- 開始ページ
- 711
- 終了ページ
- 714
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1177/0300985819839236
Porcine epidemic diarrhea virus (PEDV) induces an often fatal gastrointestinal disease in piglets. In this study, we performed a PEDV infection experiment with the Microminipig, the smallest of experimental minipigs, as a novel small animal model. We orally inoculated a neonatal Microminipig with an intestinal homogenate of a PEDV-infected pig and housed it in a small cage originally designed for rats in an animal biosafety level 2 facility. The infected Microminipig showed the typical signs of porcine epidemic diarrhea (PED), such as watery diarrhea, loss of appetite and weight loss. We also recognized a high amount of excreted PEDV in its rectal swabs and villus atrophy of the small intestine. These results suggest that the Microminipig is a good small animal model for PED, which may contribute to a better understanding of the pathogenesis of PEDV.
- リンク情報
- ID情報
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- DOI : 10.1177/0300985819839236
- ORCIDのPut Code : 58882891
- PubMed ID : 30991905