論文

査読有り 筆頭著者
2014年

The functional significance of newly born neurons integrated into olfactory bulb circuits

Frontiers in Neuroscience
  • Masayuki Sakamoto
  • ,
  • Ryoichiro Kageyama
  • ,
  • Itaru Imayoshi

8
8
開始ページ
121
終了ページ
記述言語
英語
掲載種別
DOI
10.3389/fnins.2014.00121
出版者・発行元
Frontiers Research Foundation

The olfactory bulb (OB) is the first central processing center for olfactory information connecting with higher areas in the brain, and this neuronal circuitry mediates a variety of odor-evoked behavioral responses. In the adult mammalian brain, continuous neurogenesis occurs in two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the hippocampal dentate gyrus. New neurons born in the SVZ migrate through the rostral migratory stream and are integrated into the neuronal circuits of the OB throughout life. The significance of this continuous supply of new neurons in the OB has been implicated in plasticity and memory regulation. Two decades of huge investigation in adult neurogenesis revealed the biological importance of integration of new neurons into the olfactory circuits. In this review, we highlight the recent findings about the physiological functions of newly generated neurons in rodent OB circuits and then discuss the contribution of neurogenesis in the brain function. Finally, we introduce cutting edge technologies to monitor and manipulate the activity of new neurons. © 2014 Sakamoto, Kageyama and Imayoshi.

リンク情報
DOI
https://doi.org/10.3389/fnins.2014.00121
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24904263
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346482800001&DestApp=WOS_CPL
ID情報
  • DOI : 10.3389/fnins.2014.00121
  • ISSN : 1662-453X
  • ISSN : 1662-4548
  • PubMed ID : 24904263
  • SCOPUS ID : 84904966562
  • Web of Science ID : WOS:000346482800001

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